dla pacjentów i lekarzy
Onkologia - aktualności medyczne dla lekarzy
Progression-Free Survival and Overall Survival Significantly Longer with Lenvatinib Plus Pembrolizumab Than with Chemotherapy in Advanced Endometrial Cancer
Findings from the Study 309–KEYNOTE-775 among patients who had disease progression after the receipt of previous systemic platinum-based therapy.
On 2 February, Stella Kyriakides, European Commissioner for Health and Food Safety, will host a hybrid event entitled “Ensuring equal access to all: Cancer in Women - Europe’s Beating Cancer Plan” to raise awareness of cancer in women and to announce the latest actions under the EU’s Cancer Plan.
A Combination of Atezolizumab and Enzalutamide Does Not Improve Overall Survival in Unselected Patients with mCRPC Whose Disease Progressed on Abiraterone
In the phase III IMbassador 250 study, a combination of an immune checkpoint inhibitor atezolizumab with a second-generation oral androgen receptor antagonist enzalutamide did not improve survival over enzalutamide alone in patients with metastatic castration-resistant prostate cancer whose disease progressed on abiraterone.
AI algorithms have shown promise for grading prostate cancer, specifically in prostatectomy samples and biopsies, and by assisting pathologists in the microscopic reviews, but they are susceptible to various biases in their development and validation.
Selected patients with brain metastases (BM) are candidates for radiotherapy. A lactatogenic metabolism, common in BM, has been associated with radioresistance. We demonstrated that BM express nitric oxide (NO) synthase 2 and that administration of its substrate L-arginine decreases tumour lactate in BM patients.
TOPAZ-1: Durvalumab Plus Gemcitabine and Cisplatin Could Become New First-Line Standard of Care for Advanced Biliary Tract Cancer
TOPAZ-1, the first global phase 3 study to evaluate use of immunotherapy in the first-line setting in advanced biliary tract cancers, demonstrated that adding the PD-L1 inhibitor durvalumab to gemcitabine and cisplatin—the current first-line standard of care—significantly improves overall survival and other efficacy outcomes without exacerbating toxicity.
Incidence of regional and distant metastasis is higher in paediatric patients compared with adults with differentiated thyroid cancer. Study shows that RET and NTRK fusions are the most prevalent genetic alterations in paediatric differentiated thyroid cancer.
This textbook provides a practically applicable resource for understanding the surgical oncology management of pancreatic cancer. It discusses relevant aspects of anatomy and pathophysiology along with the latest diagnostic techniques. Insightful descriptions are then provided detailing how to perform critical surgical procedures when treating these patients.
Combination Therapies May Improve Outcomes Due to Independent, Rather Than Synergistic or Additive, Drug Action
Independent drug action, not synergy nor additivity, accounted for the clinical efficacy of nearly all examined combination therapies involving immune checkpoint inhibitors in clinical trials, according to results from a retrospective analysis published in Clinical Cancer Research.
Expanded CheckMate-649 Data Confirm the Benefit of First-Line Nivolumab Plus Chemotherapy in Metastatic Esophagogastric Cancer
Long-term efficacy and safety data for first-line nivolumab plus chemotherapy bolster its use as standard treatment in patients with advanced gastric, gastroesophageal junction, and esophageal adenocarcinoma.
Although the established treatments for stage II testicular seminoma have an excellent cure rate, the long-term toxicities and increased risk for second primary cancers associated with these approaches are a concern.
Patients with uterine carcinosarcoma and ovarian carcinosarcoma have very poor outcomes and more efficacious treatments are needed. The objective of the phase 3 randomized noninferiority GOG-0261 trial was to determine if the survival of patients with UCS or OCS receiving paclitaxel/carboplatin was inferior to patients who were treated with paclitaxel/ifosfamide.
A Phase III Study of Spartalizumab in Combination with Dabrafenib and Trametinib Did Not Meet Primary Endpoint in BRAF V600–Mutated Metastatic Melanoma
COMBI-i did not show a statistically significant difference in investigator-assessed progression-free survival in the broad population of patients with BRAF V600–mutated metastatic melanoma treated in this phase III study of spartalizumab in combination with dabrafenib and trametinib versus placebo in combination with dabrafenib and trametinib.
ASCO Optimal Adjuvant Chemotherapy and Targeted Therapy Guideline Rapid Recommendation Update: Abemaciclib With Endocrine Therapy in the Treatment of High-Risk Early Breast Cancer
ASCO Rapid Recommendations Updates highlight revisions to select ASCO guideline recommendations as a response to the emergence of new and practice-changing data. The rapid updates are supported by an evidence review and follow the guideline development processes outlined in the ASCO Guideline Methodology Manual.
Z radością informujemy, że od 1 stycznia 2022 dostęp do zasobów polskojęzycznej wersji pisma Nowotwory. Journal of Oncology, które dotychczas ukazywało się drukiem pod tytułem Nowotwory – Biuletyn Polskiego Towarzystwa Onkologicznego, zostanie otwarty dla wszystkich.
Testicular seminoma and non-seminoma: ESMO-EURACAN Clinical Practice Guideline for diagnosis, treatment and follow-up
This ESMO Clinical Practice Guideline provides key recommendations on the management of testicular seminoma and non-seminoma. Authorship includes a multidisciplinary group of experts from different institutions and countries in Europe. Key treatment recommendations are provided.
Osimertinib for adjuvant treatment of EGFR mutation-positive non-small-cell lung cancer after complete tumour resection
Osimertinib is recommended for use as adjuvant treatment after complete tumour resection in adults with stage 1b to 3a non‑small‑cell lung cancer whose tumours have epidermal growth factor receptor exon 19 deletions or exon 21 (L858R) substitution mutations. It is recommended only if osimertinib is stopped at 3 years, or earlier if there is disease recurrence or unacceptable toxicity.
Tucatinib Added to Trastuzumab and Capecitabine Continues to Demonstrate a Significant OS Improvement in Patients with HER2-positive Metastatic Breast Cancer
Continued overall survival benefit and tolerability of tucatinib in combination with trastuzumab and capecitabine, demonstrated in a final analysis of the HER2CLIMB study, augments data from the primary analysis and further supports the use of this combination in patients with previously treated HER2-positive metastatic breast cancer after progression on two HER2-targeted therapies.
Targeted therapies have dramatically improved treatment outcomes for patients with molecularly defined subsets of NSCLC, and the FDA continues to rapidly approve new therapies for NSCLC mutations/fusions in the metastatic setting.
ASCO and Ontario Health Provide Updated Recommendations on Using Adjuvant Bone-Modifying Treatments in Nonmetastatic Breast Cancer
An update to a joint guideline from Cancer Care Ontario and ASCO provides revised recommendations for the use of adjuvant bone-modifying agents for patients with nonmetastatic breast cancer with the overarching goal of improving relapse and survival rates.
Adjuvant Capecitabine-Containing Regimen Improves Modestly Overall Survival in Patients with Early Breast Cancer
The Finland Capecitabine Trial (FinXX) researchers found that addition of capecitabine to a taxane-anthracycline chemotherapy backbone improved overall survival in patients with early breast cancer during a median follow-up for 15 years after the date of random assignment.
Neoadjuvant Nivolumab Plus Ipilimumab Shows Promising Activity in Early-Stage MSI/dMMR Esophagogastric Junction and Gastric Adenocarcinoma
Neoadjuvant treatment with nivolumab and ipilimumab in patients with MSI/dMMR esophagogastric junction and gastric adenocarcinoma yielded a pathologic complete response rate of 59%—far higher than the 10% pCR rate expected with cytotoxic chemotherapy.
Adagrasib monotherapy demonstrates encouraging activity in patients with a variety of advanced KRAS G12C-mutated gastrointestinal malignancies. Notably, in patients with pancreatic ductal adenocarcinoma, single-agent adagrasib confers a 50% partial response rate and a 100% disease control rate.
Patients with metastatic CRC who had sarcopenia at baseline were more likely to experience severe neutropenia during first-line FOLFOX or FOLFIRI. The findings also suggest that lean body mass may be an important factor in determining 5-FU dosing.
Large Analysis Illustrates Advantages of Using Liquid Biopsy to Identify, Manage Disease in Patients With Advanced MSI-H GI Cancers
A large-scale analysis suggests that liquid biopsy performs about as well as tissue biopsy for identifying MSI-H in patients with advanced GI cancers and can be used successfully to guide treatment with immune checkpoint inhibitors.
Z okazji Europejskiego Tygodnia Profilaktyki Raka Szyjki Macicy PTGO chce przypomnieć Państwu obecne możliwości i wytyczne dotyczące pierwotnej i wtórnej profilaktyki w raku szyjki macicy. Zapraszamy na spotkanie 27 stycznia z Ekspertami w tej dziedzinie, Profesorem Janem Kotarskim i Profesorem Robertem Jachem.
Zarząd Sekcji Urologii Onkologicznej (SUO) Polskiego Towarzystwa Urologicznego zaprasza do wzięcia udziału w 9. Sympozjum Sekcji Urologii Onkologicznej, które odbędzie się w Warszawie w dniach 4-5 marca 2022 r. Celem spotkania jest przedstawienie wyników najnowszych badań i osiągnięć w zakresie urologii, omawianych podczas zbliżającego się spotkania European Section of Oncological Urology – ESOU.
The role of radiotherapy in metastatic renal cell carcinoma is controversial. We prospectively tested the feasibility and efficacy of radiotherapy to defer systemic therapy for patients with oligometastatic renal cell carcinoma.
Impressive Responses to PD-1 Blockade in a Large Cohort of Children and Young Adults with Recurrent/Progressive Germline DNA Replication Repair-Deficient Cancers
Study reveals impressive responses to PD-1 blockade and an associated improved survival for relapsed/refractory hypermutated cancers in children and young adults with germline DNA replication repair deficiency.
Paclitaxel and Carboplatin Not Inferior When Compared with Paclitaxel and Ifosfamide for the Treatment of Patients with Uterine Carcinosarcoma
With regard to overall survival (OS), paclitaxel and carboplatin was not inferior and demonstrated improved progression-free survival (PFS) when compared with paclitaxel and ifosfamide in patients with uterine carcinosarcoma.
Metastatic colorectal cancer (mCRC) remains a leading cause of cancer-related mortality, and amplification of the HER2 gene is the latest molecular subset to be therapeutically targetable in this disease.
Pembrolizumab Demonstrates Robust and Durable Antitumour Activity in Patients with Previously Treated Advanced MSI-H/dMMR Endometrial Cancer
Findings from the KEYNOTE-158 study support the use of pembrolizumab as a treatment option for patients with advanced MSI-H/dMMR endometrial cancer with treatment failure on prior therapy.
A new clinical guideline from the American Society for Radiation Oncology (ASTRO) provides guidance on the use of radiation therapy to treat adult patients with primary liver cancers using external beam radiation therapy (EBRT).
Selpercatinib is recommended for use as an option for treating RET fusion-positive advanced non-small-cell lung cancer (NSCLC) in adults who need systemic therapy after immunotherapy, platinum-based chemotherapy or both.
Study led by MD Anderson Cancer Center found more than two-thirds of patients with blood cancer who experienced septic shock died within 28 days.
Patients with cancer who develop breakthrough COVID-19 remain at risk of severe outcomes despite full vaccination.
Higher Rates of Metastasis-Free Survival in Men with High-Risk Non-Metastatic Prostate Cancer with Combination Treatment Than with ADT Alone
Findings from a meta-analysis of two randomised controlled phase III studies of the STAMPEDE platform protocol.
Pembrolizumab Showed Statistically Significant Improvement in Disease-Free Survival Versus Placebo as Adjuvant Treatment for Patients With Stage IB-IIIA Non-Small Cell Lung Cancer Regardless of PD-L1 Expression
Merck known as MSD outside the US and Canada, EORTC and ETOP announced that the Phase 3 KEYNOTE-091 trial, also known as EORTC-1416-LCG/ETOP-8-15 – PEARLS, investigating pembrolizumab anti-PD-1 therapy, met one of its dual primary endpoints of disease-free survival for the adjuvant treatment of patients with stage IB-IIIA non-small cell lung cancer following surgical resection regardless of PD-L1 expression.
Among premenopausal women with one to three positive lymph nodes and a recurrence score of 25 or lower, those who received chemoendocrine therapy had longer invasive disease–free survival and distant relapse–free survival than those who received endocrine-only therapy.
Dual Inhibition of LAG-3 and PD-1 in Patients with Previously Untreated Metastatic or Unresectable Melanoma
A phase II/III, RELATIVITY-047 study evaluated dual inhibition of LAG-3 and PD-1 using a new combination of LAG-3–blocking antibody relatlimab and PD-1–blocking antibody nivolumab, as compared with nivolumab alone.
Zapraszamy na kolejną edycję konferencji poświęconej chorobom jelita grubego. Konferencja odbędzie się w dniach 21-22 kwietnia 2022 roku w Krakowie. W trakcie wydarzenia poruszone zostaną aktualne tematy dotyczące nowotworów jelita grubego i technik endoskopowych.
New Treatment Options for Hepatocellular Carcinoma Raises Questions for Optimal Sequencing of Therapies
Treatment options have greatly expanded for patients with advanced hepatocellular carcinoma, with benefits seen with tyrosine kinase inhibitors, checkpoint inhibitors, and antiangiogenic antibodies.
W ramach webinaru zostaną przedstawione najnowsze doniesienia, dotyczące postępowania u chorych na nowotwory piersi, ze szczególnym uwzględnieniem tych z konferencji „San Antonio Breast Cancer Symposium 2021”. Webinar odbędzie się 14 stycznia 2022 roku.
Total neoadjuvant therapy (TNT), which is full chemotherapy and chemoradiation in the preoperative period, is increasingly viewed by clinicians as the treatment of first resort, perhaps even the standard of care. No single protocol for TNT exists, making treatment selection challenging.
Combining Immunotherapy With Neoadjuvant Chemoradiation in the Treatment of Locally Advanced, Resectable Esophago-Gastric Cancers
The role of immunotherapy in the treatment of locally advanced, resectable esophago-gastric cancers is expanding, with recent ASCO guidelines advocating the selective utilization of immune checkpoint inhibition in the adjuvant setting after trimodality therapy.
The therapeutic landscape for patients with relapsed/refractory multiple myeloma (MM) continues to evolve with the introduction of new targets and advances in cellular therapy and immunology.
Protecting People with Cancer from COVID-19: New Recommendations from Cancer Guidelines Organization
National Comprehensive Cancer Network published significant updates to the expert consensus recommendations on vaccination and pre-exposure prophylaxis of COVID-19 in people with cancer.
Radioligand therapy with 177Lu-PSMA-617 prolonged imaging-based progression-free survival and overall survival when added to standard care in patients with advanced PSMA-positive metastatic castration-resistant prostate cancer.
New indication concerns the treatment of patients with metastatic colorectal cancer for whom due to toxicity is not possible to continue treatment with another fluoropyrimidine.
EMA adopted a positive opinion, recommending the granting of a marketing authorisation for the medicinal product tepotinib, intended for the treatment of patients with advanced non-small cell lung cancer harbouring alterations leading to mesenchymal-epithelial transition factor gene exon 14 (METex14) skipping.
Guideline Update Highlights the Importance of Shared Decision - Regarding the Use of Adjuvant Therapy in Stage II Colon Cancer
ASCO has published updated guidance on the use of adjuvant therapy in the management of stage II colon cancer, providing clinicians with a newer evidence-based framework that can be used in shared decision-making with patients.
Use of Consolidation Durvalumab and Adjuvant Osimertinib Among Key Recommendations in New ASCO Guideline on Stage III NSCLC Treatment
A new ASCO guideline provides key recommendations for the evaluation and management of stage III non–small cell lung cancer (NSCLC). Recommendations made by the ASCO Expert Panel cover evaluation and staging of NSCLC, neoadjuvant and adjuvant therapy, and the management of unresectable disease.
Nivolumab Does Not Prolong Overall Survival Compared with Sorafenib In First-Line Treatment for Advanced Hepatocellular Carcinoma
In CheckMate 459 study nivolumab monotherapy did not significantly prolong overall survival (OS) compared with sorafenib as first-line treatment for patients with advanced hepatocellular carcinoma. However, nivolumab showed durable clinical activity in terms of response frequency and durability.
2021 was an exciting year for advancements in prostate cancer with novel diagnostic imaging, particularly prostate-specific membrane antigen (PSMA) and now the first theranostic targeted therapy.
The benefits of timely cystectomy must be weighed against the risks—most important, the increased morbidity and potentially decreased quality of life associated with radical surgery when compared with less invasive treatments.
Association of Antineoplastic Therapy With Decreased SARS-CoV-2 Infection Rates in Patients With Cancer
Patients who received ACE2-lowering antineoplastic compounds, including mTOR/PI3K inhibitors and antimetabolites exhibited statistically significantly lower rates of SARS-CoV-2 infection compared with patients given other antineoplastics.
Pancreatic cancer is the fifth leading cause of cancer death in Europe. As cases are almost always diagnosed at an advanced stage, and with few treatment options available, the resulting 5-year survival rates are among the lowest (<5%) of any cancer.
Tisagenlecleucel Is Safe and Effective in Pretreated Patients with Relapsed/Refractory Follicular Lymphoma
The ELARA investigators are now reporting the findings from the primary, prespecified interim analysis of their study of tisagenlecleucel in adults with relapsed/refractory follicular lymphoma after two or more treatment lines or who relapsed after autologous stem cell transplant.
EMA adopted a positive opinion recommending a change to the terms of the marketing authorisation for the medicinal product lorlatinib.bNew indication concerns the treatment of adult patients with ALK positive advanced NSCLC previously not treated with an ALK inhibitor.
EMA Recommends Granting a Marketing Authorisation for Enfortumab Vedotin for the Treatment of Urothelial
EMA adopted a positive opinion, recommending the granting of a marketing authorisation for the medicinal product enfortumab vedotin, intended for the treatment of adult patients with urothelial cancer. An antibody drug conjugate induces cytotoxicity in cancer cells by binding to the nectin-4.
The Inaugural WHO Classification of Childhood Tumors Will Provide a Unified, Updated Resource for the Diagnosis of Pediatric Cancers
The first classification of pediatric cancers soon to be published by the International Agency for Research on Cancer (IARC) as part of the new World Health Organization (WHO) Classification of Tumors series was summarized in a review article published in Cancer Discovery, a journal of the American Association for Cancer Research.
W ramach międzynarodowej współpracy pomiędzy National Comprehensive Cancer Network a Narodowym Instytutem Onkologii opublikowano pierwszą polską edycję wytycznych NCCN dotyczących leczenia nowotworów. Opracowane w wyniku współpracy ekspertów wytyczne zostały oparte na dowodach naukowych i konsensusie ekspertów. Zawierają najnowsze zalecenia dotyczące leczenia nowotworów raka szyjki macicy.
2021 has exposed the weaknesses and lack of resilience of European healthcare systems with major consequences for cancer care and cancer patients, regrettably not too different from 2020. More than ever, this past year has stressed the need for crucial attention not only to restore cancer services but to build back better and be prepared to face upcoming challenges.
Over the past 5 years, clinical trials have demonstrated a clear benefit in overall survival with the intensification of upfront systemic therapy in the first-line treatment of metastatic and high-risk localized or node-positive prostate cancer.
ASCO Guideline Update: Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy
Purpose: to increase awareness, outline strategies, and offer guidance on the recommended management of immune-related adverse events (irAEs) in patients treated with immune checkpoint inhibitor (ICPi) therapy.
FDA approved pafolacianine, an optical imaging agent, for adult patients with ovarian cancer as an adjunct for interoperative identification of malignant lesions. Pafolacianine is a fluorescent drug that targets folate receptor which may be overexpressed in ovarian cancer.
A Remarkable Group of Patients with Haematological Disorders with No or Low Immune Response After Second COVID-19 Vaccine Dose
A remarkable group of patients were measured with no or low immune response after second COVID-19 vaccine dose, especially those with lymphoid neoplasms. Of those who tested negative for vaccine-related antibodies, most were on active therapy. The study team underlined that further explorations are needed with focus on potential risk of COVID-19 infections despite full vaccination.
The European Cancer Organisation has published a Report: “Making Hope Reality: Action on Treatment and Care for Metastatic Cancer Patients”. The report provides a detailed account of the presentations and contributions shared during a special Community 365 Roundtable Meeting on Metastatic Cancer held in October 2021.
Several ongoing studies are researching the best combination strategies to improve response rates in neuroendocrine tumors with 177Lu-dotatate. Other promising treatment avenues for NETs include novel α-particle–emitting radiopharmaceuticals, as well as multireceptor tyrosine kinase inhibitors, both single agent and in combination with immune checkpoint inhibitors.
Reflecting recent significant classification changes and new data on the use of biomarkers to inform treatment for central nervous system tumors, a new guideline offers oncologists up-to-date recommendations for managing gliomas in adult neuro-oncology patients.
The European Cancer Organisation, in strong alliance with a collaboration of 22 healthcare professional and patient organisations, is today marking the publication the "Essential Requirements for Quality Cancer Care: Pancreatic Cancer”. This new consensus charter for improved care and standards for a too-long neglected tumour type.
Six Months Immunogenicity of COVID-19 mRNA-based Vaccine in Patients with Actively Treated Solid Malignancies
Results of the Vax-On study of mRNA-BNT162b2 immunogenicity in patients with actively treated solid malignancies suggest that proximity to cancer treatment does not affect seroconversion response, which remains adequate even 5 months after the second COVID-19 vaccine dose. Updated results of the Vax-On study favour the third vaccine dose for actively treated patients with cancer.
Accelerated Hypofractionated Image-Guided vs Conventional Radiotherapy for Patients With Stage II/III Non-Small Cell Lung Cancer and Poor Performance Status
This phase III randomised clinical trial found that hypofractionated IGRT (60 Gy in 15 fractions) was not superior to CFRT (60 Gy in 30 fractions) for patients with stage II/III NSCLC ineligible for concurrent chemoradiotherapy.
Limited Effect of Endocrine Therapy on Distant Metastasis-Free Interval in Patients with Stage I Low-Risk Breast Cancer, but Fewer Breast Cancer Events
With 8 years median follow-up, a subgroup of patients included in the MINDACT study with stage I oestrogen receptor (ER)-positive, HER2-negative, low-risk breast cancer who received no adjuvant systemic therapy had a good 8-year distant metastasis-free interval rate, although a slightly better outcome and lower rates of locoregional recurrence and contralateral breast cancer were observed in patients who received endocrine therapy.
FDA approved rituximab in combination with chemotherapy for paediatric patients (≥6 months to <18 years) with previously untreated, advanced stage, CD20-positive diffuse large B-cell lymphoma (DLBCL), Burkitt lymphoma (BL), Burkitt-like lymphoma (BLL), or mature B-cell acute leukaemia (B-AL).
Decyzją Zarządu Polskiego Towarzystwa Chirurgii Onkologicznej kolejny, XXVIII Zjazd PTChO w formie konferencji naukowo-szkoleniowej odbędzie się w dniach od 26 do 28 maja 2022 roku w Gdańsku. Jako przewodniczący Komitetu Organizacyjnego powołani zostali przez Zarząd profesorowie: Tomasz Jastrzębski i Zoran Stojcev.
ASCO Guideline Update: Chemotherapy and Targeted Therapy for Patients With Human Epidermal Growth Factor Receptor 2–Negative Metastatic Breast Cancer That is Either Endocrine-Pretreated or Hormone Receptor–Negative
This guideline updates recommendations of the ASCO guideline on chemotherapy and targeted therapy for patients with human epidermal growth factor receptor 2–negative metastatic breast cancer (MBC) that is either endocrine-pretreated or hormone receptor (HR)–negative.
ASCO Guideline Update: Endocrine Treatment and Targeted Therapy for Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Metastatic Breast Cancer
Purpose to update recommendations of the ASCO systemic therapy for hormone receptor (HR)-positive metastatic breast cancer (MBC) guideline. An Expert Panel conducted a systematic review to identify new, potentially practice-changing data.
ASCO Guideline: Management of Immune-Related Adverse Events in Patients Treated With Chimeric Antigen Receptor T-Cell Therapy
The multidisciplinary team issued recommendations to aid in the recognition, workup, evaluation, and management of the most common CAR T-cell–related toxicities, including cytokine release syndrome, immune effector cell–associated neurotoxicity syndrome, B-cell aplasia, cytopenias, and infections.
ASCO Updates Guidance on Use of Abemaciclib and Endocrine Therapy in Patients With High-Risk Early Breast Cancer
A rapid update to the ASCO guideline on optimal adjuvant chemotherapy and targeted therapy for early breast cancer provides guidance on the use of the oral CDK4/6 inhibitor abemaciclib with endocrine therapy (ET) in patients with high-risk early breast cancer.
Two Years of Adjuvant Palbociclib Added to Endocrine Therapy Does Not Improve Outcomes in Early Breast Cancer
The results of the final protocol-defined analysis of the PALLAS study conducted in patients with early hormone receptor-positive, HER2-negative breast cancer.
Addition of adjuvant palbociclib to standard endocrine therapy does not improve outcomes in patients with early HR-positive breast cancer.
CAR T-Cell Treatment for Adults With Relapsed/Refractory B-Cell ALL: Understanding ZUMA-3 Data and Next Steps
Based on the ZUMA-3 data, the FDA recently approved brexucabtagene autoleucel for adult patients with R/R B-ALL. CAR T cells should be incorporated in earlier lines of therapy and, importantly, in MRD-positive/low-tumor-burden disease states.
FDA approved pembrolizumab for the adjuvant treatment of adult and paediatric patients with stage IIB or IIC melanoma following complete resection. Efficacy was evaluated in KEYNOTE-716.
Lack of Benefit of Adding Immune Checkpoint Inhibitors to Chemotherapy in Low PD-L1–Expressing Gastric, Gastro-oesophageal Junction, or Oesophageal Adenocarcinoma
Although current recommendations suggest that immune checkpoint inhibitors may be used for all patients with advanced gastric, gastro-oesophageal junction, or oesophageal adenocarcinoma in the first-line setting, the analyses of previously unpublished data from pivotal phase III randomised studies fail to demonstrate a survival advantage when adding ICIs to conventional chemotherapy in patients with low PD-L1–expressing tumours.
Single-Fraction vs Multifraction Stereotactic Ablative Body Radiotherapy for Pulmonary Oligometastases (SAFRON II)
In this randomised clinical trial, neither arm demonstrated evidence of superior safety, efficacy, or symptom burden; however, single-fraction SABR is more efficient to deliver. Therefore, single-fraction SABR, as assessed by the most acceptable outcome profile from all end points, could be chosen to escalate to future studies.
When classified into gain-of-function and non–gain-of-function, p53 mutations could stratify the prognosis of right-sided versus left-sided metastatic colorectal cancer.
Nivolumab Demonstrates Clinical Benefits in a Statistically Evaluable Number of Patients with carcinoma of unknown primary
An investigator-initiated phase II study is the first to show that nivolumab has clinical activity with manageable toxicity in a statistically evaluable number of patients with carcinoma of unknown primary.
Sequencing of Bone Marrow DNA May Predict Leukemia Relapse After CAR-T Therapy With Sufficient Time to Intervene
Next-generation sequencing for minimal residual disease was highly sensitive and more accurate than flow cytometry and monitoring of B-cell aplasia. according to a study published in Blood Cancer Discovery, a journal of the American Association for Cancer Research.
This ESMO Clinical Practice Guideline provides key recommendations for diagnosis, staging and management of bladder cancer. Recommendations for personalised medicine are also included.
Malignant pleural mesothelioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
This ESMO Clinical Practice Guideline provides key recommendations for managing malignant pleural mesothelioma. The optimal diagnostic methods, pathological evaluation and staging are described.
Stanowisko Polskiego Towarzystwa Onkologicznego w sprawie projektu Ustawy o Krajowej Sieci Onkologicznej
Jak wskazuje NIK, skuteczność leczenia onkologicznego w Polsce jest gorsza niż w większości pozostałych krajów Unii Europejskiej, a według dostępnych prognoz istnieje ryzyko, że stan ten będzie się pogarszał. Tym samym potrzebne są istotne zmiany o charakterze systemowym, które przekładać się będą na poprawę wyników osiąganych w diagnozowaniu i leczeniu nowotworów.
Osimertinib is recommended for people with early-stage (1b to 3a) non-small-cell lung cancer (NSCLC) who have had surgery to remove their tumour and who have epidermal growth factor receptor (EGFR) gene mutations.
The results from a head-to-head comparison of two different neurokinin-1 receptor antagonists for the prevention of chemotherapy induced nausea and vomiting in patients receiving highly emetogenic chemotherapy.
The 6.5-year data in the pivotal CheckMate 067 study show durable, improved clinical outcomes with nivolumab plus ipilimumab or nivolumab versus ipilimumab in patients with advanced melanoma and, in descriptive analyses, with the combination over nivolumab monotherapy.
The biological effect of radiotherapy, as quantified by GARD, is significantly associated with time to first recurrence and overall survival for patients with cancer treated with radiation. It is predictive of radiotherapy benefit, and physical dose of radiation is not.
Support for the role of neoadjuvant therapy in the management of nonmetastatic pancreatic adenocarcinoma is growing. With the high risk of rapid dissemination of disease, neoadjuvant therapy allows for the immediate delivery of systemic therapy to address micrometastatic disease present in most patients with localized pancreatic cancer at the time of diagnosis.
Narodowy Instytut Onkologii zaprasza do udziału w konferencji „Warsaw Summit of European Cancer Strategies”, która odbędzie się 9 grudnia 2021r. w formie hybrydowej (w NIO w Warszawie oraz na platformie Zoom). Szczyt poświęcony będzie różnorodnym tematom związanym z walką z rakiem, europejskim sieciom onkologicznym i wdrażaniu strategii onkologicznych w Europie Środkowo-Wschodniej.
Efficacy was evaluated in AMPECT study in patients with locally advanced unresectable or metastatic malignant perivascular epithelioid cell tumour.
Będzie to czwarty w tym roku webinar organizowany przez sekcję młodych chirurgów onkologicznych. Tematyką webinaru będzie chirurgia małoinwazyjna. Czy można się nauczyć chirurgii małoinwazyjnej nie mając od kogo na oddziale? Czy trzeba być dobrym laparoskopistą aby dobrze operować robotem?
Perioperative Chemotherapy for Resectable Liver Metastases in Colorectal Cancer: Do We Have a Blind Spot?
In 2004, the MOSAIC trial demonstrated that fluoropyrimidine-oxaliplatin doublets further improved OS for stage III disease6; this led to widespread use of perioperative or adjuvant infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX) for resectable colorectal cancer liver metastases.
In a phase III, randomised DAWNA-1 study, the combination of dalpiciclib, a new cyclin-dependent kinase (CDK) 4 and 6 inhibitor, with fulvestrant improved progression-free survival with manageable safety in patients with hormone receptor (HR)-positive, HER2-negative advanced breast cancer who progressed or relapsed on endocrine therapy.
Results from the first prospective study showing that patients with HER2-amplified metastatic colorectal cancer identified by ctDNA genotyping benefit from dual-HER2 blockade similarly to patients identified by conventional tissue analysis,
Results from monotherapy group in UPSTREAM demonstrate trial’s feasibility in head and neck squamous cell carcinoma
The EORTC UPSTREAM trial set out to investigate the effect of targeting treatment to the specific gene alteration (biomarker) found in an individual patient’s tumour. Patients for whom no pre-specified biomarkers are identified in their tumour are treated by immunotherapy.
The implementation roadmap for the Europe's Beating Cancer Plan has now been published by the European Commission. It highlights the necessary steps to be taken in concrete actions towards a strong European Health Union.
It is intended for the treatment of patients with advanced NSCLC with KRAS G12C mutation who have progressed after at least one prior line of systemic therapy.
Randomised Study on Dose Escalation in Definitive Chemoradiation for Patients With Locally Advanced Esophageal Cancer
In definitive chemoradiation for esophageal cancer, radiation dose escalation up to 61.6 Gy to the primary tumour did not result in a significant increase in local control over 50.4 Gy. The absence of a dose effect was observed in both adenocarcinoma and squamous cell carcinoma.
This guideline provides evidence-based recommendations for the indications and technique-dose of external beam radiation therapy (EBRT) in hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (IHC).
FDA approved pembrolizumab for the adjuvant treatment of patients with renal cell carcinoma (RCC) at intermediate-high or high risk of recurrence following nephrectomy, or following nephrectomy and resection of metastatic lesions.
CAR T-cell therapy has recently entered standard-of-care practice for multiple myeloma with the U.S. Food and Drug Administration's approval of idecabtagene vicleucel and imminent review of ciltacabtagene autoleucel.
Study Identifies Determinants of Response to SARS-CoV-2 Vaccines Among Patients With Solid-Organ and Hematologic Malignancies
A recent study from Journal of Clinical Oncology found all 3 SARS-CoV-2 vaccines authorized for use in the United States to be well-tolerated in a large cohort of patients with solid-organ and hematologic malignancies.
Nivolumab is recommended for adjuvant treatment of completely resected oesophageal or gastro‑oesophageal junction cancer in adults who have residual disease after previous neoadjuvant chemoradiotherapy.
Fasting-mimicking Diet Is Safe, May Modulate Metabolism and Boost Antitumor Immunity in Cancer Patients
A diet involving short-term, severe calorie restriction was safe, feasible, and resulted in a decrease of blood glucose and growth factor concentration, reduction in peripheral blood immunosuppressive cells, and enhanced intratumor T-cell infiltration in cancer patients receiving standard-of-care therapy.
Results from two phase III studies, KEYNOTE-361 and IMvigor131, using combination chemotherapy and CPI therapy versus chemotherapy alone or CPI monotherapy showed no clear benefit with combination treatment.
Early Onset Is a Negative Prognostic Factor in High-Risk Stage III CRC, Hinting to Aggressive Nature of the Disease
A post hoc analysis of the database of the IDEA collaboration published in Journal of Clinical Oncology found young age to be negatively prognostic and associated with significantly higher relapse rate in patients with stage III early-onset colorectal cancer (EO-CRC), irrespective of greater treatment intensity and adherence.
DREAMseq: Upfront Dual Immunotherapy More Efficacious Than Dual Targeted Therapy for BRAFV600-Mutant Metastatic Melanoma
The randomized phase III ECOG-ACRIN EA6134 trial, also known as DREAMseq, demonstrates that for the 45% of patients with BRAFV600-mutant metastatic melanoma, starting with anti–PD-1/CTLA-4 immunotherapy confers better overall survival (OS) than starting with BRAF/MEK targeted therapy.
Six months of concomitant and adjuvant androgen suppression statistically significantly improves EFS and clinical disease-free survival in intermediate-risk prostatic carcinoma, treated by irradiation at 74 or 78 Gy. The effects on OS and DMFS did not reach statistical significance.
In ‘Earlier is Better: Advancing Cancer Screening and Early Detection’ the European Cancer Organisation, working with its dedicated Network on Prevention, Early Detection and Screening, has set out a number of pressing needs to be encapsulated in the new formal advice on cancer screening.
Immunotherapy May Yield Longer Treatment-free Survival Than Targeted Therapy in Advanced Renal Cell Carcinoma
Patients with advanced renal cell carcinoma who received the checkpoint inhibitor combination nivolumab plus ipilimumab experienced longer treatment-free survival (TFS) over a 42-month period than patients who received the targeted therapy sunitinib, regardless of the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) risk group.
Chemo-immunotherapy improves overall survival compared with chemotherapy alone and represents a new standard of care for all patients with untreated advanced esophageal squamous cell carcinoma and most patients with untreated advanced gastroesophageal adenocarcinomas.
Bispecific antibodies are molecules designed to target malignant cells and immune effector cells simultaneously, they act as a bridge between these two antigens and result in cell-mediated cytotoxicity.
Disease-free survival (DFS) is one of the most complicated endpoints in oncology. Unlike progression-free survival in the advanced cancer setting, which refers to time from treatment to disease progression (or death) in patients who already have measurable cancer in their bodies.
High-quality surgery remains the best chance to cure solid cancer when diagnosed early and is fundamental in preventing, diagnosing and staging cancer, treating metastatic disease, preserving quality of life and alleviating symptoms. However, many challenges remain to fully unlock its potential.
Randomised Phase III Trial of Prophylactic Cranial Irradiation With or Without Hippocampal Avoidance for Small-Cell Lung Cancer
Sparing the hippocampus during prophylactic cranial irradiation (PCI) better preserves cognitive function in patients with SCLC. No differences were observed with regard to brain failure, OS, and QoL compared with standard PCI.
EMA Publishes Guidance to Provide Key Methods and Good Regulatory Practices on the Planning and Conduct of Registry-Based Studies
EMA published the guideline on registry-based studies. This guideline addresses the methodological, regulatory and operational aspects involved in using registry-based studies to support regulatory decision-making.
Metastatic TNBC (mTNBC) is associated with poor prognosis. A recent analysis of France's Epidemiological Strategy and Medical Economics database showed that outcomes for mTNBC have not improved much over the last decade.
In an effort to design a more effective, time-limited regimen, BTK inhibitors have now been combined with venetoclax, with or without obinutuzumab; these combination regimens capitalize on the potentially synergistic effects of BTK and BCL-2 inhibitors.
ASCO Releases New Guidelines on the Management of Adverse Events in Patients Treated With Immune Checkpoint Inhibitors and CAR T-Cell Therapy
ASCO has released new recommendations for the management of adverse events related to two immunotherapy modalities with increasing application in cancer care—immune checkpoint inhibitors (ICIs) and CAR T-cell therapy.
FDA granted accelerated approval to asciminib for patients with Philadelphia chromosome-positive chronic myeloid leukaemia (Ph+ CML) in chronic phase (CP), previously treated with two or more tyrosine kinase inhibitors (TKIs), and approved asciminib for adult patients with Ph+ CML in CP with the T315I mutation.
Risk of Age-related Diseases May Be Higher in Younger B-cell Non-Hodgkin Lymphoma Survivors Than in Their Older Counterparts
Younger B-cell non-Hodgkin lymphoma (B-NHL) survivors had a higher relative risk of developing age-related diseases than older B-NHL survivors five years or more after cancer diagnosis, according to results published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.
Selpercatinib is recommended for use within the Cancer Drugs Fund, as an option for treating: advanced RET fusion-positive thyroid cancer in adults who need systemic therapy after sorafenib or lenvatinib, advanced RET-mutant medullary thyroid cancer in people 12 years and older who need systemic therapy after cabozantinib or vandetanib.
Predicted excess cardiovascular risk is small for most patients, so radiotherapy may provide net benefit. However, for a minority of patients receiving high doses of radiation to cardiovascular structures, it may be preferable to consider advanced radiotherapy techniques to reduce doses or to omit radiotherapy and accept the increased relapse risk.
This study suggests that all women diagnosed with triple-negative breast cancer or ER-negative breast cancer should receive genetic testing and that women over age 65 years with BRCA1 and BRCA2 PVs and perhaps with PALB2 and CHEK2 PVs should be considered for magnetic resonance imaging screening.
EMA adopted a positive opinion, recommending the granting of a conditional marketing authorisation for the medicinal product amivantamab intended for the treatment of advanced non-small cell lung cancer (NSCLC) with activating epidermal growth factor receptor (EGFR) exon 20 insertion mutations.
Apalutamide with androgen deprivation therapy for treating high-risk hormone-relapsed non-metastatic prostate cancer
Apalutamide plus androgen deprivation therapy (ADT) is recommended, within its marketing authorisation, as an option for treating hormone‑relapsed non‑metastatic prostate cancer that is at high risk of metastasising in adults. High risk is defined as a blood prostate-specific antigen (PSA) level that has doubled in 10 months or less on continuous ADT.
Apalutamide with androgen deprivation therapy for treating hormone-sensitive metastatic prostate cancer
Apalutamide plus androgen deprivation therapy (ADT) is recommended as an option for treating hormone-sensitive metastatic prostate cancer in adults, only if docetaxel is not suitable.
Patients With Early-Stage Breast Cancer Who Are Unrepresented in Clinical Trials Face Increased Mortality
New data on women with early breast cancer, presented during the 2021 ASCO Quality Care Symposium, suggest patients who are not well-represented in clinical trials may face reduced odds of survival, calling into question the generalizability of clinical trial results to real-world patients.
Long-Term Outcomes in Patients with Metastatic Melanoma Treated with Anti-PD1 Therapy Based on PET Response
FDG-PET has a predominant role in predicting long-term benefit over CT, especially in patients with no complete response. In those without CMR at 1-year, almost half will experience subsequent disease progression, such that a change in therapy could be implemented, whereas in CMR patients, FDG-PET may have a role in defining shorter treatment duration.
nab-Sirolimus Induces Rapid and Durable Responses in Patients With Malignant Perivascular Epithelioid Cell Tumors
A new study from Journal of Clinical Oncology reporting on the outcomes from the phase II AMPECT trial found that rapamycin inhibitor nab-sirolimus induces rapid and durable responses in patients with malignant perivascular epithelioid cell tumors (PEComas).
Patient Selection, Risk Management, Critical to Treating Asymptomatic Brain Metastasis in Patients With Non–Small Cell Lung Cancer
Up to a quarter of patients with advanced non–small cell lung cancer (NSCLC) that doesn't harbor a driver mutation can develop brain metastases (mets), and they contribute to neurocognitive symptoms and diminished quality of life.
Germline Pathogenic Variants in CDH1, BRCA2, CHEK2, ATM, and PALB2 Associated with Increased Risk of Invasive Lobular Carcinoma
The largest study involving multigene panel testing of women with invasive lobular carcinoma describes the frequency of germline pathogenic variants in invasive lobular carcinoma and the differences in gene-specific frequencies between invasive lobular carcinoma and infiltrating ductal carcinoma.
Patients with Non-Small-Cell Lung Cancer with Brain Metastases: New Data on the Significant Challenges for which Physicians Feel Unequipped
40 per cent of healthcare providers surveyed across the five countries in Europe and the United States feel less than well equipped to care for non-small-cell lung cancer (NSCLC) patients with brain metastases, according to a new survey carried out by Ipsos MORI in collaboration with the European Cancer Organisation.
Atezolizumab is recommended, within its marketing authorisation, as an option for untreated locally advanced or metastatic urothelial cancer in adults whose tumours express PD-L1 at a level of 5% or more and when cisplatin-containing chemotherapy is unsuitable.
NICE has published draft guidance for public consultation which does not recommend tucatinib (also called TUKYSA and made by Seagen Inc), in combination with trastuzumab and capecitabine, for some types of breast cancer that has spread.
Shortened course of radiation therapy offers similar long-term side effects following prostate removal surgery
Using fewer - but higher - doses of radiation to treat men with prostate cancer who had their prostates removed does not increase long-term side effects or lower their quality of life compared to conventional radiation treatment, a new, multi-institutional clinical trial shows.
Cure Probability Models for Evaluation of Patients with a Previous Cancer Diagnosis for Solid Organ Transplantation
Findings from a first study that applied a formal statistical framework to inform the evaluation of transplant candidates with a previous cancer diagnosis were published on 22 October 2021 in the Journal of Clinical Oncology.
Wytyczne NCCN w zakresie praktyki klinicznej w onkologii - Rak jajnika w tym rak jajowodu i pierwotny rak otrzewnej
Opublikowana została polska wersja językowa wytycznych National Comprehensive Cancer Network (NCCN) w zakresie praktyki klinicznej w onkologi dotycząca raka jajnika wraz z rakiem jajowodu i pierwotnym rakiem otrzewnej. Polska edycja powstała w ramach współpracy pomiędzy NCCN, USA a Narodowym Instytutem Onkologii im. Marii Skłodowskiej-Curie (NIO-PIB).
Genetic biomarker test predicts recurrence and survival outcomes for men with high-risk prostate cancer
A new meta-analysis finds that a genetic biomarker test accurately predicts how men with high-risk prostate cancer will respond to treatment with radiation and hormone therapy. The study indicates that physicians potentially can use genetic test scores to personalize treatment for men with the most aggressive form of prostate cancer.
Radiotherapy Versus Inguinofemoral Lymphadenectomy as Treatment for Vulvar Cancer Patients With Micrometastases in the Sentinel Node
Inguinofemoral radiotherapy is a safe alternative for IFL in patients with SN micrometastases, with minimal morbidity. For patients with SN macrometastasis, radiotherapy with a total dose of 50 Gy resulted in more isolated groin recurrences compared with IFL.
EMA adopted a positive opinion, recommending the granting of a marketing authorisation for the first-in-class medicinal product sacituzumab govitecan, intended for the treatment of unresectable or metastatic triple negative breast cancer (TNBC).
High-dose radiation therapy can be used to lengthen progression-free survival for people with advanced lung cancer when systemic therapy has not fully halted the growth or spread of metastases, according to a new study.
FDA approved atezolizumab for adjuvant treatment following resection and platinum-based chemotherapy in patients with stage II to IIIA non-small cell lung cancer (NSCLC) whose tumours have PD-L1 expression on ≥1% of tumour cells, as determined by an FDA-approved test.
Clinical trial reported at the 2021 ASCO Annual Meeting confirmed that the use of interim PET/CT scans is highly valuable as a biomarker of disease and can successfully be used to improve patient outcomes.
Nivolumab Plus Low-Dose Ipilimumab Demonstrates Clinical Benefit in First-Line Treatment for MSI-H/dMMR mCRC
Durable and deep tumour responses were observed in patients with microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer (mCRC) treated with first-line nivolumab plus low-dose ipilimumab, regardless of baseline demographic and tumour characteristics, including BRAF or KRAS mutation status.
Nivolumab for treating recurrent or metastatic squamous cell carcinoma of the head and neck after platinum-based chemotherapy
Nivolumab is recommended as an option for treating recurrent or metastatic squamous cell carcinoma of the head and neck in adults whose disease has progressed on platinum based chemotherapy, only if the disease has progressed within 6 months of having chemotherapy
Pembrolizumab with platinum- and fluoropyrimidine-based chemotherapy for untreated advanced oesophageal and gastro-oesophageal junction cancer
Pembrolizumab with platinum- and fluoropyrimidine-based chemotherapy is recommended, within its marketing authorisation, as an option for untreated locally advanced unresectable or metastatic carcinoma of the oesophagus or HER2‑negative gastro-oesophageal junction adenocarcinoma in adults whose tumours express PD‑L1 with a combined positive score (CPS) of 10 or more.
ESMO Clinical Practice Guideline for the diagnosis, staging and treatment of patients with metastatic breast cancer. Provides key recommendations and algorithms for managing metastatic breast cancer. Covers diagnosis, staging, risk assessment, treatment, disease monitoring, palliative care and the patient perspective.
Adjuvant Abemaciclib Combined with Endocrine Therapy Improves IDFS in HR-Positive, HER2−Negative, Node-Positive, High-Risk, Early Breast Cancer
Invasive disease-free survival benefit deepened and distant relapse-free survival benefit was maintained in patients with hormone receptors (HR)-positive, HER2-negative, node-positive, high risk early breast cancer treated with adjuvant CDK4/6 inhibitor, abemaciclib and endocrine therapy.
MRI with targeted and standard biopsy in men with MRI results suggestive of prostate cancer was noninferior to standard biopsy for detecting clinically significant prostate cancer in a population-based screening-by-invitation trial and resulted in less detection of clinically insignificant cancer.
Zilovertamab Vedotin Is Safe and Demonstrates Activity In Heavily Pretreated Patients With Lymphoid Malignancies
In heavily pretreated patients with lymphoid malignancies, zilovertamab vedotin demonstrated no unexpected side effects and showed evidence of antitumour activity in a phase I, first-in-human, dose-escalation study.
Webinar „Prevention and Treatment of Peritoneal Metastases: Combining Complete Cytoreductive Surgery with HIPEC”
7 listopada 2021 w niedzielę o godzinie 20.00 czasu indyjskiego (16:30 czasu polskiego) odbędzie się webinar "Prevention and Treatment of Peritoneal Metastases: Combining Complete Cytoreductive Surgery with HIPEC". Będzie to niesamowita okazja by posłuchać profesora Paula Sugarbakera z USA, ojca chirurgii HIPEC.
FDA approved pembrolizumab in combination with chemotherapy, with or without bevacizumab, for patients with persistent, recurrent or metastatic cervical cancer whose tumours express PD-L1 combined positive score (CPS) ≥1
PTCHO objęło patronatem merytorycznym warsztaty dotyczące diagnostyki biopsyjnej i leczenia chirurgicznego z rekonstrukcją gruczołu piersiowego, które odbędą się na utrwalonych preparatach anatomicznych. Warsztaty są skierowano głównie do osób w trakcie specjalizacji.
The European Cancer Organisation Publishes a Position Paper on Self-Sampling and HPV Screening in Europe
The Europe’s Beating Cancer Plan sets out recommendations for cervical cancer elimination across the EU, including an ambitious goal to offer screening to 90% of the eligible population by 2025. The ECO today publishes a new Position Paper “Self-Sampling and HPV Screening in Europe” with recommendations that will help member states achieve this.
EMA adopted a positive opinion recommending a change to the terms of the marketing authorisation for the medicinal product pembrolizumab. New indication concerns the treatment of PD-L1 positive locally recurrent unresectable or metastatic TNBC.
American Association for Cancer Research (AACR) released the 11th edition of its annual Cancer Progress Report, which underscores how cancer research, largely supported by federal investments in the National Institutes of Health (NIH) and the National Cancer Institute (NCI), continues to drive progress for patients with cancer.
A Third Dose of BNT162b2 is Safe and Improves Humoural Immunity Against SARS-CoV-2 in Patients with Solid Tumours
Researchers reported the serological and cellular immune responses after two-dose BNT162b2 vaccination of patients with solid tumours on active cytotoxic chemotherapy compared to healthy controls and the outcomes of a phase I study of a third vaccine dose subsequently initiated in the cancer cohort.
Merging the Histologic and Molecular Data Into an Integrated Score Significantly Improves Precision in Stratification of Meningiomas
Retrospectively and prospectively validated data from a multicentre retrospective analysis allowed to the German Consortium on Aggressive Meningiomas researchers to devise and validate an integrated score that leverages the advantages of WHO grading, specific copy-number variations (CNVs), and methylation-based classifications.
Amerykańskie Towarzystwo Radioterapii Onkologicznej (ASTRO) przedstawiło zestawienie najważniejszych badań, których wyniki zostaną omówione podczas dorocznego Kongresu ASTRO, który odbędzie się 24 -27 października w Chicago w formie tradycyjnej oraz online.
Prof. Iwona Ługowska, Ruth Plummer i Paulo A. Ascierto napisali „Melanoma and other skin cancers” – dwuczęściowy informator – przewodnik poświęcony czerniakowi i innym rodzajom raka skóry. Powodem tej publikacji są nowe możliwości leczenia pacjentów. Autorzy zebrali dostępną sobie wiedzę i dzielą się nią ze środowiskiem medycznym w nowej publikacji.
FDA granted recognition to a partial listing of the Memorial Sloan Kettering Cancer Center’s Oncology Knowledge Base (OncoKB) as the first tumour mutation database to be included in the Public Human Genetic Variant Database.
A Peptide-drug Conjugate that Targets the Acidic Environment of Cancer Cells May Improve the Efficacy of Immunotherapy
A peptide-drug conjugate that targets the acidic environment of cancer cells enhanced the efficacy of immune checkpoint inhibitors in preclinical cancer models, according to results presented at the AACR-NCI-EORTC Virtual International Conference.
Inhibition of the Aurora Kinase A Protein May Help Overcome Lung Cancer Resistance to KRAS Inhibition
In preclinical models, combining an investigational Aurora Kinase A (AURKA) inhibitor with a KRAS inhibitor or a WEE1 inhibitor showed efficacy against lung cancer cells with intrinsic or acquired resistance to KRAS inhibition.
Adding ErbB Tyrosine Kinase Inhibitor to KRAS Inhibitor May Help Circumvent Lung Cancer Resistance to Prior Therapies
Combination of the KRAS inhibitor sotorasib (Lumakras) with afatinib, a pan-ErbB tyrosine kinaseinhibitor, was feasible in treating non-small cell lung cancer (NSCLC) patients with mutated KRAS whose disease had progressed on prior therapies, including KRAS inhibitors alone.
DNA Alkylation Drug May Improve Outcomes for Adolescents and Young Adults With Central Nervous System Tumors
In a phase II clinical trial, the drug 4-demethyl-4-cholesteryloxycarbonylpenclomedine (DM-CHOC-PEN) improved survival for some adolescent and young adult (AYA) patients with cancers involving the central nervous system, according to results presented at the AACR-NCI-EORTC Virtual International Conference.
FDA Approves Brexucabtagene Autoleucel for Relapsed or Refractory B-Cell Precursor Acute Lymphoblastic Leukaemia
FDA approved brexucabtagene autoleucel for adult patients with relapsed or refractory B-cell precursor acute lymphoblastic leukaemia (ALL). Efficacy was evaluated in ZUMA-3 study that evaluated brexucabtagene autoleucel, a CD19-directed chimeric antigen receptor (CAR) T-cell therapy, in adults with relapsed or refractory B-cell precursor ALL.
Elevated allostatic load was associated with a lower likelihood of completing chemotherapy and a lower overall survival rate in patients with lymph node-positive or high-risk lymph node-negative HER2-negative breast cancer.
Adjuvant Chemotherapy Customisation Based on ERCC1 and TS mRNA Levels Does Not Improve Efficacy in Resected NSCLC
ITACA study was open-label, randomised, investigator-initiated study to evaluate the predictive utility of ERCC1 and TS mRNA expression levels in completely resected stage II-IIIA non-small cell lung cancer. The results indicate that adjuvant chemotherapy customisation based on ERCC1 and TS mRNA levels did not improve efficacy.
Promising FOCUS4-C Findings Warrant Further Study of WEE1 Blockade in TP53- and RAS-Mutant Metastatic Colorectal Cancer
Adavosertib, an investigational small-molecule inhibitor of WEE1, demonstrated encouraging efficacy and favorable safety in the phase II FOCUS4-C trial conducted in 69 patients with metastatic colorectal cancer (CRC) featuring TP53 and RAS mutations.
W ramach konkursu Agencja Badań Medycznych dofinansuje projekty przewidujące utworzenie i rozwój Onkologicznych Centrów Wsparcia Badań Klinicznych (OnkoCWBK). Inicjatywa ma na celu zwiększenie liczby zarówno badań klinicznych w obszarze onkologii, zwiększenie liczby uczestników w Polsce, a także wykorzystanie potencjału sektora badań klinicznych komercyjnych i niekomercyjnych.
EMA adopted a positive opinion, recommending the granting of a marketing authorisation for the medicinal product ripretinib, intended for the treatment of advanced gastrointestinal stromal tumour (GIST) in patients who have received prior treatment with three or more kinase inhibitors.
Abiraterone Acetate Plus Prednisone and LHRH Analogue is Active and Safe in AR-Expressing, Castration-Resistant Salivary Gland Carcinoma
The primary aim of the phase II study was reached, demonstrating for the first time that abiraterone acetate combined with prednisone and luteinizing hormone-releasing hormone (LHRH) analogue is active in castration-resistant, androgen receptor (AR)-positive salivary gland carcinoma.
New indication concerns the first-line treatment of adult patients with HER2-negative advanced or metastatic gastric, GEJ or oesophageal adenocarcinoma.
Patients Treated With Chemotherapy and B Cell–Targeting Agents Show Impaired Serological Response to COVID-19 Vaccination
Findings from the largest study to measure anti-SARS-CoV-2 antibody levels after vaccination in patients with haematological and solid malignant tumours.
Immunotherapy in Patients With Locally Advanced Esophageal Carcinoma: ASCO Treatment of Locally Advanced Esophageal Carcinoma Guideline Rapid Recommendation Update
ASCO Rapid Recommendations Updates highlight revisions to select ASCO guideline recommendations as a response to the emergence of new and practice-changing data. The rapid updates are supported by an evidence review and follow the guideline development processes outlined in the ASCO Guideline Methodology Manual.
FOCUS4-N Supports a Treatment Break as a Sound Alternative to Maintenance Therapy in Metastatic Colorectal Cancer
The meta-analysis, like FOCUS4-N, showed that “although maintenance therapies can extend the time to progression, they have no impact on OS. This includes the standard range of therapies, capecitabine and bevacizumab being the cardinal ones.
FDA approved cabozantinib for adult and paediatric patients 12 years of age and older with locally advanced or metastatic differentiated thyroid cancer (DTC) that has progressed following prior vascular endothelial growth factor receptor (VEGFR)-targeted therapy and who are ineligible or refractory to radioactive iodine.
Atezolizumab has been recommended by NICE for people whose tumour expresses PD-L1 at a level of 5% of more and when platinum-containing chemotherapy is unsuitable. The recommendation comes after additional clinical evidence which showed that people who have atezolizumab are likely to live up to 8 months longer than those who have platinum-containing chemotherapy.
Changes in patient-reported outcomes (PROs) seen after just 1 month predicted for treatment response and survival outcomes in patients with advanced gastrointestinal cancers, according to data presented during the 2021 ASCO Quality Care Symposium.
In a phase II study conducted by the MD Anderson Cancer Center researchers, poziotinib resulted in a 27% confirmed partial response (PR) rate and a median progression-free survival (PFS) of 5 months in patients with advanced HER2 exon 20 mutated non-small cell lung cancer (NSCLC).
This article focuses on the recent immunotherapy updates to the treatment of renal cell carcinoma (RCC) as given in the RCC: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
EMA adopted a positive opinion, recommending the granting of a conditional marketing authorisation for the medicinal product pralsetinib, intended for the treatment of patients with rearranged during transfection (RET) fusion positive non-small cell lung cancer (NSCLC).
Rybocyklib z najdłuższą medianą przeżycia całkowitego kiedykolwiek zaobserwowaną w zaawansowanym HR+/HER2-ujemnym raku piersi
Rybocyklib w skojarzeniu z letrozolem, u kobiet w wieku pomenopauzalnym z zaawansowanym rakiem piersi typu HR+/HER2-, pozwolił osiągnąć medianę przeżycia całkowitego wynoszącą ponad 5 lat (63,9 miesiąca), korzyść w zakresie przeżycia wyniosła ponad 12 miesiący.
Patients with advanced oesophageal cancer having SEMS insertion for the primary management of their dysphagia did not gain additional benefit from concurrent palliative radiotherapy and it should not be routinely offered.
Treatment with Tebentafusp Results in Longer Overall Survival Among Previously Untreated Patients with Metastatic Uveal Melanoma
In the randomised, phase III study, treatment with tebentafusp, a soluble T-cell receptor and CD3-directed bispecific fusion protein, was associated with longer overall survival (OS) than the investigator’s choice of therapy in HLA-A*02:01– positive patients with metastatic uveal melanoma.
Vax-On Points to Maintenance of Active Anticancer Treatment Throughout the Whole COVID-19 Vaccination Schedule
In a large population of patients with solid tumours undergoing active anticancer treatment, the researchers confirmed a favourable safety profile of mRNA-BNT162b2 vaccine, which may reassure on maintaining active anticancer treatment throughout the whole vaccination schedule.
New research in JNCCN finds four out of five cancer therapies tested in Phase III trials do not achieve clinically-meaningful benefit in prolonging survival, and is the first study to quantify the number of false-positive, false-negative, and true-negative trial results.
FDA Grants Accelerated Approval to Tisotumab Vedotin-tftv for Recurrent or Metastatic Cervical Cancer
FDA granted accelerated approval to tisotumab vedotin-tftv, a tissue factor-directed antibody and microtubule inhibitor conjugate, for adult patients with recurrent or metastatic cervical cancer with disease progression on or after chemotherapy.
The findings from the first randomised study that evaluated the addition of an epidermal growth factor receptor (EGFR) antibody to fluorouracil/folinic acid maintenance therapy in patients with RAS wild-type metastatic colorectal cancer show that panitumumab adds efficacy to fluorouracil/folinic acid as maintenance therapy in terms of progression-free survival.
Radioembolization Delays Disease Progression in Patients With Unresectable Colorectal Liver Metastases
Long-awaited findings from the EPOCH trial demonstrate that a locoregional therapy can confer a clinically meaningful benefit in patients with systemic disease. This randomized phase III trial conducted over 8 years in individuals with unresectable colorectal liver metastases.
In soft tissue sarcomas (STS), several aspects about multifocal disease (MFD) —the presence of two or more discontiguous tumors within one body location —are still unclear. Liposarcoma is the most common histologic subtype to have MFD, but it can also occur in angiosarcoma.
A Novel Combination of Cabozantinib Plus Atezolizumab Demonstrates Encouraging Activity and Acceptable Tolerability in Advanced RCC
In the COSMIC-021 study, cabozantinib plus atezolizumab demonstrated encouraging clinical activity in patients with advanced renal cell carcinoma (RCC). Robust clinical activity was observed across dose levels and histologic subtypes.
People with intellectual disability are at an increased risk of any cancer, as well as several specific cancer types. The findings from a population-based cohort study of Swedish children born to mothers from the Nordic countries suggest a need for extended surveillance and early intervention in cancer among people with intellectual disability.
Gastrointestinal stromal tumours: ESMO-EURACAN-GENTURIS Clinical Practice Guideline for diagnosis, treatment and follow-up. This Clinical Practice Guideline provides key recommendations on the management of gastrointestinal stromal tumours. Recommendations have been agreed following a consensus meeting of representatives from ESMO, EURACAN and GENTURIS.
Neoadjuvant chemotherapy with FOLFIRINOX and preoperative chemoradiotherapy for patients with locally advanced rectal cancer
Intensification of chemotherapy using FOLFIRINOX before preoperative chemoradiotherapy significantly improved outcomes compared with preoperative chemoradiotherapy in patients with cT3 or cT4 M0 rectal cancer. The significantly improved disease-free survival in the neoadjuvant chemotherapy group and the decreased neurotoxicity indicates that the perioperative approach is more efficient and better tolerated than adjuvant chemotherapy.
Pembrolizumab Does Not Prolong Overall Survival Compared to Chemotherapy in Platinum-Pretreated Recurrent or Metastatic Nasopharyngeal Carcinoma
According to results of the KEYNOTE-122, multicentre, open-label, randomised phase III study that evaluated the efficacy and safety of pembrolizumab versus chemotherapy in patients with platinum-pretreated, recurrent or metastatic nasopharyngeal carcinoma, pembrolizumab did not prolong overall survival (OS) over chemotherapy in that population.
Automated Detection of Microsatellite Status in Early Colon Cancer by Infrared Imaging Combined with Artificial Intelligence
The researchers of PRODI used tissue sections from the prospective multicentre AIO ColoPredictPlus 2.0 registry study to verify the novel label-free infrared (IR) imaging combined with artificial intelligence (AI) for tumour detection and classification of microsatellite status. They reported that AI integrated IR imaging can automatically classify unstained tumour sections precisely in less than 30 min.
Copanlisib Combined with Rituximab Shows Superior Efficacy over Placebo and Rituximab in Relapsed Marginal Zone Lymphoma
A subset analysis of the randomised, double-blind, placebo-controlled phase III CHRONOS-3 study that focused on patients with relapsed marginal zone lymphoma, showed superior efficacy of treatment with a PI3K inhibitor, copanlisib plus rituximab compared to placebo plus rituximab.
FDA granted accelerated approval to zanubrutinib (Brukinsa, BeiGene) for adult patients with relapsed or refractory marginal zone lymphoma (MZL) who have received at least one anti-CD20-based regimen.
New results from immunotherapy trials from the EORTC gynaecological and lung cancer groups presented at ESMO 2021
Late-breaking results from two Phase 2 EORTC trials of immunotherapy were presented at the 2021 ESMO congress on Friday 17 September. Immunotherapy drugs are relatively new additions to cancer treatment, and work by stimulating the immune system so that it can find and attack cancer cells.
Organ-Sparing Potentials from the Neoadjuvant Pembrolizumab Treatment in Patients with dMMR/MSI-H Solid Tumours
In a phase II open-label study performed among patients with localised, unresectable or high risk resectable, microsatellite instability high (MSI-H)/deficient mismatch repair (dMMR) solid tumours, treatment with neoadjuvant pembrolizumab was safe and resulted in high rates of radiographic and endoscopic responses.
Deep Learning Model Applied to Digital Pathology Slides Could Predict the Risk of Relapse in Invasive Breast Cancer
To better identify patients with early breast cancer who are at risk of relapse, the researchers from the startup Owkin and Gustave Roussy conceived a diagnostic tool that applies deep learning to digital pathology slides and clinical data. They showed that their model could predict the risk of relapse in patients with oestrogen receptor (ER)-positive, HER2-negative early breast cancer.
Tolerability, pharmacokinetics and efficacy of samuraciclib were assessed in a first-in-human, modular study. Treatment with this first-in-class, oral, selective inhibitor of CDK7 demonstrated an acceptable safety profile and evidence of antitumour activity in patients with advanced solid tumours.
Trastuzumab Deruxtecan Demonstrates Robust and Durable Activity in Previously Treated Metastatic NSCLC with HER2 mutations
The DESTINY-Lung01 study assessed the efficacy and safety of HER2 antibody-drug conjugate trastuzumab deruxtecan in patients with metastatic non-small cell lung cancer (NSCLC) with HER2 mutations. Trastuzumab deruxtecan demonstrated robust and durable activity in this population, with a manageable safety profile.
Ruszył kolejny cykl bezpłatnych szkoleń szkoleń online dla pielęgniarek/pielęgniarzy i personelu medycznego. Do końca roku zaplanowano 10 spotkań w następujących modułach tematycznych: leczenie przeciwnowotworowe, wybrane problemy współczesnej onkologii, powikłania w leczeniu onkologicznym, leczenie wspomagające w onkologii, praktyczne aspekty opieki pielęgniarskiej.
Extended Adjuvant Treatment with Letrozole Results in Longer Survival in Postmenopausal Patients with Breast Cancer
According to results from a prospective, open-label, phase III study conducted among the postmenopausal patients with stage I to III breast cancer who were treated with 2 to 3 years of tamoxifen, extended treatment with 5 years of letrozole resulted in longer disease-free survival (DFS) and overall survival (OS) compared to the treatment with 2 to 3 years of letrozole.
For the first time since 20 years in the bladder peri-operative setting, the authors have design a randomised phase III controlled study comparing the efficacy of GC or dd-MVAC in patients for whom chemotherapy has been decided before or after surgery.
Intermittent Relacorilant Combined with Nab-paclitaxel Improves PFS in Recurrent Platinum-Resistant Ovarian Cancer
In the first randomised, controlled study to explore the efficacy and safety of relacorilant, a selective glucocorticoid receptor modulator, in combination with nab-paclitaxel compared to nab-paclitaxel alone, combined treatment improved progression-free survival (PFS) and showed a favourable safety profile among the women with recurrent platinum-resistant and/or platinum-refractory ovarian cancer.
Epcoritamab Shows a Manageable Safety and Robust Antitumour Activity in Heavily Pretreated B-Cell Non-Hodgkin Lymphoma
Epcoritamab is a highly selective and potent bispecific antibody for CD3 and CD20 that induces T-cell-mediated cytotoxic activity against CD20-positive malignant B-cells. In a first-in-human phase I/II study subcutaneous epcoritamab was safely administered in patients with relapsed or refractory B-cell non-Hodgkin lymphoma.
How diabetes mellitus affects the efficacy of immune checkpoint inhibitors (ICIs) is yet to be defined. It prompted the investigators from 21 Italian and 1 UK institutions to evaluate the impact of diabetes mellitus in a retrospective cohort of patients with advanced cancer treated with a single-agent ICI.
Considering Cost and Toxicity Choosing Between CDK4/6 and mTOR Inhibitors for the Treatment of Breast Cancer
The CDK4/6 pathway and PI3K/AKT/mTOR pathway are implicated in the development of resistance to endocrine therapy. In vivo studies show that PI3K and mTOR inhibition can restore sensitivity to endocrine therapy.
Determining How to Treat Chemosensitive Sarcomas: Evaluating Patient Risk of Recurrence and Death Plays an Important Role
The question of using adjuvant chemotherapy in adult patients with soft tissue sarcoma is an important one. Although most patients who present with localized disease can be cured with wide local excision alone, previous data showed that about half of these patients will die of subsequent metastatic disease.
An interim analysis of the clinical study suggested that the risk of sudden or cardiac death in patients on an ACE inhibitor when entering the study was increased in patients randomised to ibrutinib and rituximab, compared to those randomised to fludarabine, cyclophosphamide and rituximab.
Abemaciclib with fulvestrant for treating hormone receptor-positive, HER2-negative advanced breast cancer after endocrine therapy
Abemaciclib plus fulvestrant is recommended as an option for treating hormone receptor‑positive, human epidermal growth factor receptor 2 (HER2)‑negative, locally advanced or metastatic breast cancer in adults who have had endocrine therapy only if exemestane plus everolimus is the most appropriate alternative to a cyclin‑dependent kinase 4 and 6 (CDK 4/6) inhibitor.
In the TROG 13.01 phase II randomised clinical study that compared single-fraction versus multifraction stereotactic ablative radiation therapy (SABR) in patients with pulmonary metastases, the researchers demonstrated that neither arm was superior in terms of safety, efficacy, or symptom burden; however, single-fraction SABR is of shorter duration and more efficient to deliver.
Lack of Evidence for the Use of Telemedicine in the Prevention and Surveillance for Recurrences and New Cancers
There is a lack of evidence on the use of telemedicine in the prevention and surveillance for recurrences and new cancers, as well as in the management of chronic medical conditions, and health promotion. The findings were published on 9 September 2021 in the Annals of Oncology.
Adjuvant temozolomide chemotherapy, but not concurrent temozolomide chemotherapy, was associated with a survival benefit in patients with 1p/19q non-co-deleted anaplastic glioma. Clinical benefit was dependent on IDH1 and IDH2 mutational status.
Pivotal Role of the Institutional Molecular Tumour Board in Evaluating the Results of a Customised Next-Generation Sequencing Panel
Results of a molecular-based approach using a customised next-generation sequencing (NGS) panel at a single academic institution were published in the British Journal of Cancer. The molecular screening aimed to select the best potential therapeutic strategy for patients with advanced cancer to receive the treatment within the early clinical study programme.
Adjuvant PARP Inhibitors in Patients With High-Risk Early-Stage HER2-Negative Breast Cancer and Germline BRCA Mutations: ASCO Hereditary Breast Cancer Guideline Rapid Recommendation Update
A significant improvement in invasive and distant disease-free survival constituted a strong signal for an update of the 2020 ASCO-ASTRO-SSO guideline recommendation focused specifically on the role of PARP inhibitors in patients with early-stage, HER2-negative breast cancer and germline BRCA mutations.
No Benefit of Additional Tumour Testing in HER2-negative Metastatic Breast Cancer with Already Confirmed Germline BRCA Mutations
According to findings from a prespecified exploratory analysis of the OlympiAD study, in patients with HER2-negative metastatic breast cancer and already confirmed germline BRCA mutations, there is no clear benefit of additional tumour testing for the homologous recombination deficiency (HRD) score or detection of gene-specific loss of heterozygosity (LOH) to determine if they are likely to respond to the treatment with PARP inhibitor.
The policy paper „Comprehensive Cancer Care Across the EU: Advancing the Vision” provides essential points of advance on implementing the commitment of the European Commission to develop a new EU Network of Comprehensive Cancer Centres and meet an objective of 90% of eligible cancer patients achieving access to such Centres by 2030.
The draft guidance looks at treating prostate cancer in adults which no longer responds to hormone therapy and who are at high risk of the cancer spreading to other parts of their body, or is still sensitive to hormone therapy but has already spread.
Nivolumab plus ipilimumab and 2 cycles of platinum-doublet chemotherapy is not recommended, within its marketing authorisation, for untreated metastatic non-small-cell lung cancer (NSCLC) in adults whose tumours have no epidermal growth factor receptor (EGFR) or anaplastic lymphoma kinase (ALK) mutations.
More Than 25 Additional Years Needed to Slow an Increasing Incidence of Oropharyngeal Cancer by Current HPV Vaccination Rate
According to the projections of the population-based age-period-cohort study performed by a group of the authors from the Johns Hopkins University in Baltimore, who published their findings on 2 September 2021 in the JAMA Oncology, current human papillomavirus (HPV) vaccination rate will have a limited association with overall incidence of oropharyngeal cancer until 2045 because older individuals who are not vaccinated remain at high risk.
Considering specificities of non-small cell lung cancer (NSCLC) biology and corresponding treatment strategies for advanced disease, a group of experts from Memorial Sloan Kettering Cancer Centre in New York, proposed a practical, clinical definition of acquired resistance to PD-(L)1 blockade for use in clinical reports and prospective clinical studies.
Phase III Randomised Trial of Prophylactic Cranial Irradiation With or Without Hippocampus Avoidance in SCLC
This randomised phase III trial did not find a lower probability of cognitive decline in patients with SCLC receiving HA-PCI compared with conventional PCI. No increase in brain metastases at two years was observed in the HA-PCI arm.
In a study published in the Nature Cancer, the research team from National Cancer Centre Research Institute in Tokyo, Japan took advantage of cancer cells purified from malignant ascites and established corresponding cell lines as the resources for genomic analyses to overcome the technical limitations associated with analyses of primary tumours.
W dniach 2-4 września 2021 odbywa się w Poznaniu XXVII Zjazd Polskiego Towarzystwa Chirurgii Onkologicznej, pierwszy zjazd tego Towarzystwa po pandemii z osobistym udziałem jego członków. Przewodniczącym Zjazdu jest prof. Dawid Murawa, obecny Prezes PTChO. Zjazd odbywa się pod patronatem m.in. Marszałka Senatu prof. Tomasz Grodzkiego, który sam jest chirurgiem zajmującym się leczeniem chorych onkologicznych.
A Personalised Prediction Model Based on Clinical and Genomic Data Outperforms Established Prognostic Models in MDS
New prediction model can provide probability of survival and leukaemia transformation at diagnosis of myelodysplastic syndrome and throughout a patient's disease course.
Recent reports (USA) suggest 20% to 40% of all patients with cancer use cannabis in some form during or after treatment. Among those patients who use cannabis, two-thirds report using it to help manage pain, anxiety, or insomnia. However, the science and clinical knowledge of cannabis fall significantly behind state laws.
Assuring high-quality, equitable care for every patient with cancer is a key part of ASCO's mission. According to Devika Das, MD, MSHQS, a member of ASCO's International Quality Task Force, the field of quality studies is in the beginning stages of a metamorphosis that will likely only accelerate over the next few years.
The discovery of molecular alterations has led to a significant improvement in the outcomes of patients with advanced lung cancer. Recently, the results of the ADAURA study established osimertinib as the standard-of-care adjuvant therapy in resectable NSCLC with sensitizing mutations in the EGFR gene, marking the entry of targeted therapy in the treatment landscape of early-stage disease.
Early and locally advanced non-small-cell lung cancer: an update of the ESMO Clinical Practice Guidelines focusing on diagnosis, staging and systemic and local therapy
Surveillance and Early Cancer Detection are Associated with Improved Survival in Constitutional Mismatch Repair Deficiency Syndrome
Constitutional mismatch repair deficiency syndrome is a cancer predisposition syndrome associated with inheritance of biallelic pathogenic variants in mismatch repair (MMR) genes leading to deficient MMR during DNA replication. It is characterised by early-onset synchronous and metachronous multiorgan tumours.
Inguinofemoral Radiotherapy Could Spare Patients with Vulvar Cancer and Sentinel Node Micrometastases the Morbidity of Lymphadenectomy
Inguinofemoral radiotherapy for patients with vulvar cancer and micrometastases in the sentinel node is safe alternative for inguinofemoral lymphadenectomy according to the GROINSS-V-II study investigators. The radiotherapy side effects were acceptable with less frequent treatment-related morbidity compared with inguinofemoral lymphadenectomy.
NCCN announced significant updates to the NCCN: Cancer and COVID-19 Vaccination guidance. This is the fourth version of NCCN’s COVID-19 vaccination guide and incorporates the latest data plus recent approvals from the FDA and CDC regarding a third mRNA vaccine dose for immunocompromised people.
FDA approved ivosidenib for adult patients with previously treated, locally advanced or metastatic cholangiocarcinoma with an isocitrate dehydrogenase-1 (IDH1) mutation as detected by an FDA-approved test.
Neoadjuvant durvalumab with or without stereotactic body radiotherapy in patients with early-stage non-small-cell lung cancer
Neoadjuvant durvalumab combined with stereotactic body radiotherapy is well tolerated, safe, and associated with a high major pathological response rate. This neoadjuvant strategy should be validated in a larger trial.
Impact of Multigene Germline Genetic Testing on Selection of Germline-Directed Therapy in Patients with Metastatic or Recurrent Cancer
27.08 Among 11,947 patients with metastatic or recurrent cancer that spanned across more than 50 different tumour types, 8% of patients had a tumour with germline alteration considered therapeutically actionable and 3.2% of these patients received germline genotype–directed treatment.
W dniach od 10 do 15 grudnia odbędą się 9. warsztaty interdyscyplinarne „Perioperative Management in CRS and HIPEC of Peritoneal Malignancy”. Organizatorem warsztatów jest Charité - University Medicine Berlin. Warsztaty odbywają się pod patronatem towarzystw medycznych: DGAV, BDC, BDA, DGAI oraz ESSO.
Ability of Deep Learning to Accurately Diagnose Frequent STS Subtypes from Conventional Histopathological Slides
Findings from one of the first studies to investigate the use of artificial intelligence in the pathological management of soft tissue sarcoma (STS) show that a deep learning model was able to classify five of the most common STS subtypes from histology alone. When aided by the deep learning model, pathologists were more accurate, faster, and more certain in their diagnosis.
Among all patients with neuroendocrine tumors (NETs), the risk of dying of cancer was higher than that of dying of other causes, but mortality varies by primary tumor site, according to a new study published in the August 2021 issue of JNCCN—Journal of the National Comprehensive Cancer Network.
Novel Trial Finds Benefit of Combination Chemotherapy for Patients With Relapsed/Progressive Rhabdomyosarcoma
Findings from the first randomized controlled trial of temozolomide plus vincristine-irinotecan (VI) among pediatric and adult patients with relapsed/progressive rhabdomyosarcoma (RMS; VIT-0910 trial) suggest the combination chemotherapy improves efficacy over VI alone.
The role of immunotherapy as first-line treatment for advanced urothelial cancer in patients not eligible for cisplatin therapy is uncertain. Carboplatin-containing regimens were previously the standard of care, but outcomes were poor.2 Accelerated approvals were given to atezolizumab and pembrolizumab based on phase II data.
The phase III KEYNOTE-775 study compared combination lenvatinib/pembrolizumab with standard single-agent chemotherapy in 827 patients with advanced, metastatic, or recurrent EC progressing after prior platinum-based chemotherapy. Immunotherapy led to a significant improvement of ORR, PFS, and OS when compared to chemotherapy.
Polskie Towarzystwo Chirurgii Onkologicznej zaprasza na kurs „Diagnostyka inwazyjna gruczołu piersiowego”, który odbędzie się 1 września 2021 w Szpitalu Uniwersyteckim w Zielonej Górze. Ilość miejsc ograniczona do 10 osób – decyduje kolejność zgłoszeń.
Pemigatinib for treating relapsed or refractory advanced cholangiocarcinoma with FGFR2 fusion or rearrangement
Pemigatinib is recommended, within its marketing authorisation, as an option for treating locally advanced or metastatic cholangiocarcinoma with a fibroblast growth factor receptor 2 (FGFR2) fusion or rearrangement that has progressed after systemic therapy in adults.
In KEYNOTE-061 randomised study, PD-1 blockade with immune checkpoint inhibitor (ICI) pembrolizumab did not significantly improve overall survival (OS) over paclitaxel in second-line treatment for advanced gastric/gastro-oesophageal junction (GEJ) adenocarcinoma with PD-L1 combined positive score (CPS) ≥1.
FDA approved nivolumab for the adjuvant treatment of patients with urothelial carcinoma (UC) who are at high risk of recurrence after undergoing radical resection. Evidence for efficacy in the adjuvant treatment of patients with high-risk urothelial carcinoma is based on the results of CHECKMATE-274 study.
Badanie prowadzone przez naukowców z University of Texas MD Anderson Cancer Center wykazało znaczący związek między przyjmowaniem leków obniżających poziom cholesterolu, powszechnie znanych jako statyny, a wskaźnikami przeżycia pacjentek z potrójnie negatywnym rakiem piersi (TNBC).
A cell therapy with autologous tumour-infiltrating lymphocytes (TILs), followed by maintenance nivolumab, was safe and clinically active upon initial progression on nivolumab monotherapy in patients with metastatic non-small cell lung cancer (NSCLC).
The HILUS-Trial-a Prospective Nordic Multicenter Phase II Study of Ultracentral Lung Tumours Treated With Stereotactic Body Radiotherapy
On the basis of the presented data, 7.0 Gy × 8.0, prescribed to the planning target volume-encompassing isodose, should not be used for tumours located within 1 cm from the main bronchi and trachea. Group B-type tumours may be considered for the treatment on the basis of an individual risk-benefit assessment.
FDA granted accelerated approval to dostarlimab-gxly for adult patients with mismatch repair deficient (dMMR) recurrent or advanced solid tumours, as determined by an FDA-approved test, that have progressed on or following prior treatment and who have no satisfactory alternative treatment options.
Guideline Rapid Update Provides New Direction on the Care of Patients With Residual Disease in Locally Advanced Esophageal Cancer
An ASCO guideline rapid update is revising recommendations for the management of locally advanced esophageal carcinoma to include provision of nivolumab following adjuvant chemoradiotherapy (CRT) and surgery.
Adoptive Transfer of Tumor-infiltrating Lymphocytes May Be Less Effective in Patients With Pretreated Metastatic Melanoma
Patients with metastatic melanoma that had relapsed on anti-PD-1 therapies or BRAF/MEK inhibitors did not respond as well to an investigational therapy that involves the adoptive cell transfer of tumor-infiltrating lymphocytes as patients naive to these treatments, according to results of a study published in Clinical Cancer Research Journal.
The results from a phase III clinical study provide the first clinical evidence that sparing the hippocampus during prophylactic cranial irradiation (PCI) better preserves cognitive function in patients with small-cell lung cancer (SCLC).
Seminoma is a relatively rare and highly curable disease that occurs mainly in young men. Treatment usually affects the patient's quality of life with long-term toxicities. The treatment of clinical stage I seminoma is still debatable. Clinical management is variable and guidelines do not recommend one therapy over another.
Przed XXVII Zjazdem PTChO, odbędzie się dwudniowy kurs „Wprowadzenie do specjalizacji z chirurgii onkologicznej”. Kurs odbędzie się w dniach 1 i 2 września w Poznaniu, w Hotelu Novotel Poznań Centrum.
Abiraterone with prednisone or prednisolone plus androgen deprivation therapy (ADT) is not recommended, within its marketing authorisation, for treating newly diagnosed high-risk hormone sensitive metastatic prostate cancer in adults.
Study findings point to potential to integrate prior antibiotic exposure in decision-making process for first-line treatment of advanced non-small cell lung cancer.
Patients Want Complementary and Alternative Treatments; Here's How to Implement Integrative Oncology Into Practice
Treatment of cancer, as it turns out, requires much more than establishing and executing a drug therapy plan. To address some of these questions, an oncologist might refer the patient to a nutritionist and to a physical therapist.
Immunoterapia stała się ważnym narzędziem w leczeniu raka płuc, zwłaszcza terapie z wykorzystaniem inhibitorów punktów kontrolnych, które blokują wybrane mechanizmy kontrolne systemu immunologicznego, pozwalając komórkom odpornościowym na efektywniejsze rozpoznawanie i zabijanie komórek nowotworowych.
This ESMO Clinical Practice Guideline provides key recommendations for managing the last weeks and days of life for the adult cancer patient with advanced cancer.
FDA approved belzutifan a hypoxia-inducible factor inhibitor for adult patients with von Hippel-Lindau (VHL) disease who require therapy for associated renal cell carcinoma (RCC), central nervous system (CNS) hemangioblastomas, or pancreatic neuroendocrine tumours (pNET), not requiring immediate surgery.
Total neoadjuvant therapy (TNT) is often used to downstage locally advanced rectal cancer (LARC) and decrease locoregional relapse; however, more than one-third of patients develop recurrent metastatic disease. As such, novel combinations are needed.
A Blood-Based, Multigenomic Signature is an Effective Diagnostic and Has Clinical Utility in NETs Management
The 51-gene expression-based liquid biopsy accurately diagnoses neuroendocrine tumours and is an effective surrogate marker compared to chromogranin A.
Abemaciclib plus fulvestrant is recommended as an option for treating hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative, locally advanced or metastatic breast cancer in adults who have had endocrine therapy.
Elucidating a Risk of Developing Second Primary Malignancy During and After Treatment with PARP Inhibitors
Although PARP inhibitors interfere with DNA repair processes leading to warnings in terms of risk for developing second primary malignancies, findings from a systematic review and safety meta-analysis of placebo-controlled randomised controlled studies are reassuring for patients starting PARP inhibitors in the first-line setting that there is no increased risk of developing second primary malignancies.
FDA approved the combination of lenvatinib plus pembrolizumab for first-line treatment of adult patients with advanced renal cell carcinoma. Evidence for efficacy of combination treatment is based the results of the CLEAR study.
Through the years, doxorubicin has been considered the gold standard as first-line cytotoxic chemotherapy in most patients with advanced soft-tissue sarcomas. This was based on the landmark EORTC 62012 study.
Pathogenic Variant Probability in High-Risk Genes Supports Genetic Testing in Older Women With Breast Cancer
here is mounting evidence that all women diagnosed with breast cancer, including those age 65 and older at diagnosis, should receive genetic testing. This is supported by results from a recent study.
A major gap remains between guidelines advocating for information and counseling on fertility preservation for all patients at risk of cancer-related infertility and the reality of practice in oncology settings.
Similar Disease-Free Survival with Extended Intermittent or Continuous Treatment with Letrozole in Breast Cancer
Final results of the Study of Letrozole Extension (SOLE) indicate that treatment with intermittent letrozole did not show superiority in terms of disease-free survival compared with continuous treatment in the extended adjuvant setting for postmenopausal women with hormone receptor-positive breast cancers.
PZWL razem z kierownikiem naukowym prof. dr hab. n. med. Jadwigą Dwilewicz-Trojaczek, zaprosił wybitnych specjalistów hematologów i onkologów do przedstawienia aktualnej wiedzy na temat diagnostyki oraz leczenia nowotworów układu krwiotwórczego i chłonnego.
Prof. Jean-Yves Blay of the Université Claude Bérard in Lyon, France and colleagues reported on 2 August 2021 in the Annals of Oncology findings from an analysis of the clinical efficacy of COVID-19 vaccination in a series of 1503 patients with cancer under active treatment for cancer.
Stereotactic body radiotherapy versus conventional external beam radiotherapy in patients with painful spinal metastases
Stereotactic body radiotherapy at a dose of 24 Gy in two daily fractions was superior to conventional external beam radiotherapy at a dose of 20 Gy in five daily fractions in improving the complete response rate for pain. These results suggest that use of conformal, image-guided, stereotactically dose-escalated radiotherapy is appropriate in the palliative setting for symptom control for selected patients with painful spinal metastases.
First-in-class Histone Deacetylase Inhibitor Gel Shows Promise for the Treatment of Patients with Basal Cell Carcinoma
Remetinostat, a topical cream and first-in-class inhibitor of histone deacetylation, showed signs of clinical efficacy in patients with basal cell carcinoma, according to results from a phase II clinical trial published in Clinical Cancer Research, a journal of the American Association for Cancer Research.
ER-Low Positive Breast Cancer Shows Similar Clinical Behaviour and Response to Neoadjuvant Chemotherapy to TNBC
In a monoinstitutional study, the investigators evaluated clinical outcomes in patients with oestrogen receptor (ER)-low positive, HER2-negative, stage I-III breast cancer as compared to patients with triple-negative breast cancer (TNBC) undergoing (neo)adjuvant chemotherapy.
A new era in cancer treatment dawned with the first FDA approval for CD19 antigen–directed chimeric antigen receptor (CAR) T-cell therapy in 2017 for acute lymphoblastic leukemia. Since then, new constructs have been approved for high-grade B-cell lymphomas, mantle cell lymphoma, follicular lymphoma, and multiple myeloma.
PZWL zaprasza na kolejną edycję wirtualnej akademii. Wybitni specjaliści omówią najbardziej palące tematy leczenia wspomagającego w onkologii. Wydarzenie jest bezpłatne i przeznaczone dla lekarzy wszystkich specjalizacji uczestniczących w procesie leczenia chorych na nowotwory.
Avapritinib Not Superior to Regorafenib in Terms of Median PFS in Third-Line or Later Treatment of Patients with Unresectable or Metastatic GIST
Findings from phase III VOYAGER study indicate that avapritinib is not superior to regorafenib in terms of median progression-free survival (PFS) in third-line or later treatment of patients with molecularly unselected unresectable or metastatic gastrointestinal stromal tumour.
Amivantamab demonstrated robust and durable responses in patients with epidermal growth factor receptor Exon 20 insertion (EGFR Exon20ins)-mutated non-small cell lung cancer (NSCLC) after progression on standard-of-care platinum-based chemotherapy.
Recently, interest has risen regarding HER2-directed therapies in central nervous system (CNS) metastases for patients with HER2-positive metastatic breast cancer; new data have shown promising activity among newer HER2-targeted agents.
Ixazomib Shows Clinically Meaningful, But Not Statistically Significant, Survival Benefit in Patients With Relapsed/Refractory Multiple Myeloma
Final overall survival (OS) analysis of the phase III TOURMALINE-MM1 trial found that ixazomib produces clinically meaningful, albeit statistically insignificant, improvement in OS in patients with relapsed/refractory multiple myeloma.
Despite adjustment for previously unmeasured confounders, breast-conserving surgery with radiotherapy yielded better survival than mastectomy irrespective of radiotherapy. If both interventions are valid options, mastectomy should not be regarded as equal to breast conservation.
Phase III study results point to noninferiority of acalabrutinib, while it provides improved safety in patients with previously treated chronic lymphocytic leukaemia.
FDA approved pembrolizumab for high-risk, early-stage, triple-negative breast cancer (TNBC) in combination with chemotherapy as neoadjuvant treatment, and then continued as a single agent as adjuvant treatment after surgery. KEYNOTE-522 study was the basis for approval in the neoadjuvant and adjuvant setting.
Rak wątroby – nowa terapia pozwala na leczenie chirurgiczne pacjentów, którzy według obecnych kryteriów zostali uznani za nieuleczalnie chorych
Połączenie kabozantynibu, leku będącego inhibitorem kinazy, oraz stosowanego w immunoterapii niwolumabu, może umożliwić leczenie chirurgiczne u niektórych pacjentów z rakiem wątroby, którzy ze względu na stopień zaawansowania nowotworu normalnie zostaliby uznani za przypadki nieoperacyjne.
Combined hormone/radiotherapy treatment improves event-free and disease-free survival in patients with localised intermediate risk prostate cancer
Adding ADT to EBRT to patients with localised intermediate risk prostate cancer significantly increases their event-free survival (EFS)1 and disease-free survival (DFS)2, and these effects are still evident after 12 years of median follow-up, say the investigators in the latest results from an EORTC trial published in The Journal of Clinical Oncology this week.
In light of findings from multiple recent clinical trials in HER2-negative metastatic breast cancer, ASCO has revised its treatment recommendations to inform more evidence-based care for metastatic breast cancer. This guideline update provides important clinical guidance about the new use of immune checkpoint inhibitors, antibody-drug conjugates, and PARP inhibitors.
A recently updated ASCO guideline offers both new and revised guidance on the treatment of hormone receptor (HR)–positive, HER2-negative metastatic breast cancer. Update encourages use of CDK4/6 inhibitors, alpelisib.
EMA adopted a positive opinion, recommending the granting of a marketing authorisation for the medicinal product Imatinib Koanaa, intended for the treatment of leukaemia and gastrointestinal stromal tumours.
During the last year, a flurry of clinical trial data have provided greater insight into mechanisms of novel therapies for breast cancer management. Some of these data, including abstracts presented during the 2021 ASCO Annual Meeting, have wide practice-changing implications in triple-negative breast cancer (TNBC) or patients with high-risk, HER2-negative, early-stage disease.
Advances in Targeted Therapies, Immunotherapy Improve Treatment Options for Patients With Lung Cancer
Major advances in lung cancer announced during the 2021 ASCO Annual Meeting follow a year of stunning progress in targeted therapies and immunotherapy that has energized the field. We have seen more progress in the development of targeted therapies and improvement in the lives of our patients in the last 5 years than over the past 25 years in the lung cancer space.
Recent analysis of large case-control data sets allows for the assessment of many additional genes associated with breast cancer, including ATM, BARD1, CDH1, CHEK2, NF1, PALB2, PTEN, RAD51C, and RAD51D, and offers compelling insights on hereditary breast cancer genetics.
Nivolumab with ipilimumab for previously treated metastatic colorectal cancer with high microsatellite instability or mismatch repair deficiency
Clinical trial evidence suggests that nivolumab plus ipilimumab may extend how long people live. The most relevant trial did not directly compare nivolumab plus ipilimumab with usual treatments, but indirect comparisons suggest that it substantially increases how long it takes for the cancer to get worse and how long people live.
Healthy lifestyle factors such as abstinence from smoking and drinking, low body mass index, and exercise correlated with decreased cancer incidence, even in individuals with a high genetic risk, according to results of a study published in Cancer Research, a journal of the American Association for Cancer Research.
Updated worldwide estimates of cancers associated with alcohol consumption stratified by gender, tumour localisation and country indicate causal relation of alcohol with a substantial number of cancer cases that could potentially be avoided. Among all new cancers in 2020, 4.1% were related to alcohol consumption.
W dniu 3.09.2021 rozpocznie się dwudniowa konferencja „Rak piersi – aktualne zalecenia w zakresie leczenia miejscowego i programów lekowych”. Sesja pierwsza będzie poświęcona problemom radioterapii po rekonstrukcji piersi. Organizatorzy zachęcają polskie ośrodki chirurgiczne i radioterapeutyczne do podzielenia się swoimi doświadczeniami w tym zakresie.
High-dose versus standard-dose twice-daily thoracic radiotherapy for patients with limited stage small-cell lung cancer
The higher radiotherapy dose of 60 Gy resulted in a substantial survival improvement compared with 45 Gy, without increased toxicity, suggesting that twice-daily thoracic radiotherapy of 60 Gy is an alternative to existing schedules.
A new clinical guideline from the American Society for Radiation Oncology (ASTRO) provides guidance on the use of radiation therapy to treat adult patients with soft tissue sarcoma (STS).
Women Over Age 65 Years with Pathogenic Variants in Cancer Predisposition Genes Continue to Be at Increased Risk of Breast Cancer
Women over age 65 years with pathogenic variants in cancer predisposition genes rarely benefit from hereditary cancer genetic testing. A population-based study examined whether women in this age category may qualify for clinical genetic testing and magnetic resonance imaging (MRI) screening.
Withdrawal concerns the application to extend the use of atezolizumab to include the treatment of early or locally advanced triple-negative breast cancer.
FDA approved pembrolizumab in combination with lenvatinib for patients with advanced endometrial carcinoma that is not microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR), who have disease progression following prior systemic therapy in any setting and are not candidates for curative surgery or radiation.
Some people who have a rare form of bile duct cancer are set to benefit from life-extending treatment pemigatinib after NICE published final draft guidance today (22nd July 2021).
Prefrail and Frail Young Adult Survivors of Childhood Cancers Experience Significant Neurocognitive Decline
Over a 5-year follow-up interval, frail young adult survivors of childhood cancers experienced significantly larger declines than nonfrail survivors in memory, attention, processing speed, and executive function domains.
Pembrolizumab Demonstrates Robust, Durable Antitumour Activity and Promising Survival in Advanced Cutaneous Squamous Cell Carcinoma
The results of the second interim analysis of the KEYNOTE-629 study that include initial data for the locally advanced cohort and updated data for the recurrent/metastatic cohort of patients with cutaneous squamous cell carcinoma confirm durable pembrolizumab antitumour activity and promising survival in both settings.
How the CROWN Study Affects Treatment of Patients With ALK-Positive Metastatic Non–Small Cell Lung Cancer
Based on data from the CROWN study, lorlatinib is now approved by the U.S. Food and Drug Administration for use in patients with newly diagnosed advanced ALK-positive non–small cell lung cancer (NSCLC), joining ceritinib, alectinib, brigatinib, and ensartinib.
Prognostic Significance of Lynch-like versus Sporadic MSI-H Endometrial Cancer Treated With Pembrolizumab
In a single-arm, open-label phase II study, the investigators evaluated pembrolizumab in patients with recurrent mismatch repair deficient (dMMR) and/or microsatellite instability-high (MSI-H) endometrial cancer.
Chemoradiotherapy and MRI-based IGABT result in effective and stable long-term local control across all stages of locally advanced cervical cancer, with a limited severe morbidity per organ. These results represent a positive breakthrough in the treatment of locally advanced cervical cancer, which might be used as a benchmark for clinical practice and all future studies.
FDA approved belumosudil, a kinase inhibitor, for adult and paediatric patients 12 years and older with chronic graft-versus-host disease (chronic GVHD) after failure of at least two prior lines of systemic therapy.
Hypogammaglobulinemia and Sars-CoV-2 Viraemia Determine COVID-19 Severity in Patients with Haematological Malignancies
Team of scientists investigated clinical factors associated with higher risk for severe COVID-19 in patients with haematological malignancies. They wrote in the Annals of Oncology that the coronavirus infection itself, rather than cytokine storm, lead to severe and lethal COVID-19 in these patients.
Ficlatuzumab Plus Chemotherapy Shows Promise for the Treatment of Patients with Relapsed/Refractory Acute Myeloid Leukemia
The investigational therapeutic ficlatuzumab in combination with chemotherapy showed signs of clinical efficacy in patients with relapsed/refractory acute myeloid leukemia, according to results published in Blood Cancer Discovery, a journal of the American Association for Cancer Research.
40% of cancers are preventable. For this reason, both the European Union and World Health Organization actively support countries in policy propositions that can assist in addressing modifiable cancer risks. But are there opportunities to move faster and go further? A new report by the European Cancer Organisation suggests so.
Combined MRI-directed and Standard Biopsy in Men With Elevated PSA and Positive Results on MRI Non-inferior to Standard Biopsy
In a study of population-based screening by invitation, the results showed that among men with elevated PSA levels, combined biopsy performed only in men who had positive results on magnetic resonance imaging (MRI) was non-inferior to standard biopsy for detecting clinically significant prostate cancer.
The National Cancer Institute definition of survivorship stipulates that a cancer survivor as an individual is considered to be a survivor from the time of diagnosis to the end of life. It acknowledges that cancer treatment and its consequences do not end when a specific cancer-directed therapy ends, while also implying that the road to recovery and adaptation can begin as soon as a patient is diagnosed.
Approximately 50% of patients with muscle-invasive urothelial carcinoma develop metastatic disease within 2 years of radical cystectomy alone, which commonly leads to death.1 Clinicians and researchers have strived for decades to improve this metastasis rate by integrating systemic therapy.
Incremental Progress, Reassuring Results Featured Among Gynecologic Malignancies Research at 2021 ASCO Annual Meeting
Although several studies in gynecologic malignancies have potential to change practice down the road, the OUTBACK trial on adjuvant chemotherapy in cervical cancer was the most impactful work presented at this year's Annual Meeting.
Cabazitaxel has proven benefit as a second-line therapy for patients with mCRPC who have progressed rapidly (< 12 months) through prior ASTI treatment. Immunotherapy for prostate cancer remains under clinical investigation, with pembrolizumab indicated only for prostate cancers with MSI-high or TMB-high molecular phenotypes.
Adjuvant Platinum Chemotherapy Does Not Improve Outcomes in Patients With Triple-Negative Breast Cancer With Residual Disease
Recently published findings from the phase III EA1131 trial show that, compared to capecitabine, adjuvant platinum chemotherapy does not improve outcomes in patients with triple-negative breast cancer (TNBC) with residual disease.
FDA Approves Daratumumab and Hyaluronidase-fihj With Pomalidomide and Dexamethasone for Multiple Myeloma
FDA approved daratumumab and hyaluronidase-fihj in combination with pomalidomide and dexamethasone for adult patients with multiple myeloma who have received at least one prior line of therapy including lenalidomide and a proteasome inhibitor.
FDA Approves Asparaginase Erwinia Chrysanthemi (Recombinant)-rywn for Acute Lymphoblastic Leukaemia and Lymphoblastic Lymphoma
FDA approved asparaginase erwinia chrysanthemi (recombinant)-rywn as a component of a multi-agent chemotherapeutic regimen for the treatment of acute lymphoblastic leukaemia (ALL) and lymphoblastic lymphoma (LBL) in adult and paediatric patients 1 month or older who have developed hypersensitivity to E. coli-derived asparaginase.
Avelumab plus standard-of-care chemoradiotherapy versus chemoradiotherapy alone in patients with locally advanced squamous cell carcinoma of the head and neck
The primary objective of prolonging progression-free survival with avelumab plus chemoradiotherapy followed by avelumab maintenance in patients with locally advanced squamous cell carcinoma of the head and neck was not met. These findings may help inform the design of future trials investigating the combination of immune checkpoint inhibitors plus CRT.
FDA Grants Regular Approval to Enfortumab Vedotin-ejfv for Locally Advanced or Metastatic Urothelial Cancer
FDA approved enfortumab vedotin-ejfv, a Nectin-4-directed antibody and microtubule inhibitor conjugate, for adult patients with locally advanced or metastatic urothelial cancer who have previously received a PD1 or PD-L1 inhibitor and platinum-containing chemotherapy, or are ineligible for cisplatin-containing chemotherapy and have previously received one or more prior lines of therapy.
Analysis of the Gut Microbiome Provides Clues to Survival Following Nivolumab Therapy for Advanced Gastric Cancer
A team of investigators from Japan detected several genomic pathways and bacterial genera in the pre-treatment gut microbiome of patients with advanced gastric cancer that were significantly associated with survival times following treatment with nivolumab. These findings were presented at the ESMO World Congress on Gastrointestinal Cancer 2021.
Longer-Term Follow-Up of Breast Cancer Trials Add Further Insight Into Efficacy of Promising Combination Regimens
Several pivotal trials in recent years have contributed to greater understanding of the durability and efficacy of certain novel combination regimens for breast cancer. Long-term follow-up data from three trials HER2CLIMB, PALOMA-3, and MONALEESA-3—further established these therapeutic regimens as potentially important components of clinical care.
Research has repeatedly shown that geriatric assessment, toxicity risk tools, comanagement strategies, and multidisciplinary care models are more accurate than traditional performance status metrics to evaluate older patients with cancer.
Adding Avelumab to Preoperative Chemoradiotherapy Provides Promising Anti-Tumour Activity in Locally Advanced Rectal Cancer
Many patients with locally advanced rectal cancer receiving a preoperative regimen of standard chemoradiotherapy plus avelumab achieved pathological complete response and the majority of patients showed a major pathological response, according to findings from a phase II AVANA study presented at the ESMO World Congress on Gastrointestinal Cancer 2021.
It is intended for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) who are not eligible for autologous stem-cell transplant (ASCT).
Enzalutamide plus androgen deprivation therapy (ADT) is recommended, within its marketing authorisation, as an option for treating hormone-sensitive metastatic prostate cancer in adults.
Nivolumab is recommended as an option for treating locally advanced or metastatic non-squamous non-small-cell lung cancer (NSCLC) in adults after chemotherapy, only if: their tumours are PD-L1 positive, and it is stopped at 2 years of uninterrupted treatment, or earlier if their disease progresses, and they have not had a PD-1 or PD-L1 inhibitor before.
Expression of AR-regulated Genes in CTCs Is Prognostic for Survival and Radiographic Progression in Metastatic Prostate Cancer
07.07 Novel liquid biopsy technology to collect mRNA from circulating tumour cells (CTCs) may be used to measure expression of androgen receptor (AR) splice variants, AR targets, and neuroendocrine prostate cancer markers.
The management of acquired resistance to EGFR-mutated non–small cell lung cancer (NSCLC) has undergone significant change since osimertinib was approved by FDA for first-line treatment of the most common EGFR-activating mutations, EGFR E19del and L858R, in December 2020.
At least 42% of newly diagnosed cancers in the United States are potentially avoidable because they are attributable to lifestyle factors such as smoking, alcohol consumption, poor nutrition, and lack of physical activity.
Age is perhaps the most significant risk factor for cancer incidence. With increased longevity of the population, early detection, and more effective therapies, the number of older patients with cancer and survivors of cancer will continue to rise.
20 listopada 2021 roku, w sobotę, odbędzie się konferencja „UroScrabble”. Wydarzenie kierowane jest do urologów, onkologów, nefrologów, lekarzy rodzinnych oraz wszystkich specjalistów zainteresowanych tematyką wyszczególnioną w programie.
Trastuzumab deruxtecan demonstrated clinically meaningful benefit across specific subgroups of patients with HER2-positive and HER2-low advanced gastric cancer according to findings from a post-hoc exploratory biomarker analysis presented at the ESMO World Congress on Gastrointestinal Cancer 2021.
Radiotherapy plays an important role in breast cancer management. After breast-conserving surgery, radiotherapy reduces the probability of recurrence and improves overall survival. Adjuvant whole-breast irradiation (WBI) was previously delivered in daily treatments, given over five–six weeks. These treatments, coupled with other multidisciplinary advances such as increasing the use of systemic therapy, yielded outstanding outcomes.
First-Line Encorafenib, Binimetinib, and Cetuximab Combination Provides Clinical Benefit and Manageable Safety in BRAF V600E–Mutated mCRC
Almost half of patients with previously untreated BRAF V600E–mutated metastatic colorectal cancer (mCRC), who generally have a poorer prognosis, demonstrated response and 88% showed disease control following combination treatment with encorafenib, binimetinib, and cetuximab.
Preoperative ctDNA Levels Are Detectable in the Majority of Patients with Resectable Colorectal Cancer
A team of investigators in Japan used a personalised assay for circulating tumour DNA (ctDNA) levels in plasma to monitor minimal residual disease following surgery in patients with resectable colorectal cancer. Their subgroup analysis found statistically significant associations between ctDNA levels and the pathological disease stage.
ctDNA Analysis is Feasible for Detection of Minimal Residual Disease After Treatment Across a Variety of MMRd Tumour Types
Circulating tumour DNA analysis is a feasible tumour agnostic approach for evaluation of the efficacy of checkpoint blockade in patients at high risk of recurrence.
Characterisation of KRAS, Including KRAS G12C, Mutations in Gastrointestinal and Metastatic Colorectal Cancer
Three studies delineating the prevalence of KRAS mutations in gastrointestinal and colorectal cancer, with specific focus on the KRAS G12C mutation, and an evaluation of patient outcomes according to the mutation status were presented at the ESMO World Congress on Gastrointestinal Cancer 2021.
Over the past decade, immunotherapies have transformed the treatment of patients with certain aggressive cancers, including lung and melanoma. However, less progress has been made in difficult-to-treat brain tumors. But data presented during the 2021 ASCO Annual Meeting offered promising findings for patients with unique subtypes of brain tumors.
New Research Exploring the Role of Pembrolizumab in Locally Advanced Oral Cancers Warrants Further Investigation
The incidence of oral cancer is increasing in young adults and in adults who have never smoked, representing a high unmet need. New research on neoadjuvant pembrolizumab suggests that immunotherapy may play a promising role in locally advanced oral cancers.
Obese patients with colorectal cancer receive lower cumulative doses of adjuvant chemotherapy, relative to their body surface area (BSA), than non-obese patients, show results from a large meta-analysis reported at the ESMO World Congress on Gastrointestinal Cancer 2021.
Doctors and patients are being advised to reduce unnecessary antibiotic use following new data suggesting that these medicines may increase the risk of cancer of the large intestine (colon), especially in people under 50 years.
The Investigational PD1 Antibody, Tislelizumab, Shows Promise in Patients With Unresectable Hepatocellular Carcinoma
A novel anti-PD1 agent, tislelizumab, is under development for the treatment of patients with solid tumours and has demonstrated clinical benefit in unresectable hepatocellular carcinoma (HCC), according to findings from a phase II study presented at the ESMO World Congress on Gastrointestinal Cancer 2021.
New indication concerns adjuvant treatment of oesophageal or gastro-oesophageal junction cancer with residual disease following prior neoadjuvant chemoradiotherapy.
Sexual health problems, including genital symptoms, changes in sexual response, and psychosocial issues, are prevalent in women with cancer, yet these patients are rarely asked about their sexual concerns. Oncology teams must commit to assessing and addressing sexual health, and multiple resources are available for the busy professional.
The ASCO Annual Meeting Plenary Session consistently features some of the most important treatment advances that have occurred over the past year across the broad spectrum of cancers. We asked experts to share their thoughts on the five randomized phase III clinical trials presented during the 2021 Session and how the results of these trials are likely to influence clinical practice.
Ovarian cancer carries a heavy morbidity and mortality burden, particularly in settings and regions of the globe that feature significant limitations in health care resources. Given that ovarian cancer is more lethal than breast cancer, clinicians in resource-limited areas require guidance on the appropriate assessment and treatment of patients with this disease.